The Biology of Vasopressin

被引：29

作者：

Sparapani, Samantha ^{[1
]}

Millet-Boureima, Cassandra ^{[1
]}

Oliver, Joshua ^{[1
]}

Mu, Kathy ^{[1
]}

Hadavi, Pegah ^{[1
]}

Kalostian, Tamar ^{[1
]}

Ali, Nazifa ^{[1
]}

Avelar, Carla Maria ^{[1
]}

Bardies, Marion ^{[1
]}

Barrow, Brenton ^{[1
]}

Benedikt, Minky ^{[1
]}

Biancardi, Giuliana ^{[1
]}

Bindra, Raminder ^{[1
]}

Bui, Lisa ^{[1
]}

Chihab, Zakaria ^{[1
]}

Cossitt, Ashley ^{[1
]}

Costa, Jeffrey ^{[1
]}

Daigneault, Tina ^{[1
]}

Dault, Jocelyn ^{[1
]}

Davidson, Isa ^{[1
]}

Dias, Jonathan ^{[1
]}

Dufour, Emie ^{[1
]}

El-Khoury, Sabine ^{[1
]}

Farhangdoost, Nargess ^{[1
]}

Forget, Anika ^{[1
]}

Fox, Alexa ^{[1
]}

Gebrael, Myriam ^{[1
]}

Gentile, Maria Concetta ^{[1
]}

Geraci, Olivia ^{[1
]}

Gnanapragasam, Ansley ^{[1
]}

Gomah, Elias ^{[1
]}

Haber, Elie ^{[1
]}

Hamel, Claudia ^{[1
]}

Iyanker, Thivya ^{[1
]}

Kalantzis, Christina ^{[1
]}

Kamali, Sara ^{[1
]}

Kassardjian, Elsa ^{[1
]}

Kontos, Hryssi Krissy ^{[1
]}

Le, Thi Bich Uyen ^{[1
]}

LoScerbo, Daniella ^{[1
]}

Low, Yan Fang ^{[1
]}

Mac Rae, Danielle ^{[1
]}

Maurer, Flore ^{[1
]}

Mazhar, Sana ^{[1
]}

Nguyen, Alice ^{[1
]}

Nguyen-Duong, Kathy ^{[1
]}

Osborne-Laroche, Chelsea ^{[1
]}

Park, Hwi Wun ^{[1
]}

Parolin, Emilie ^{[1
]}

Paul-Cole, Kahlila ^{[1
]}

机构：

[1] Concordia Univ, Dept Biol, Montreal, PQ H4B 1R6, Canada

来源：

BIOMEDICINES | 2021年 / 9卷 / 01期

关键词：

vasopressin; renal function; cardiac function; social behavior; sex differences; GPCRs; POLYCYSTIC KIDNEY-DISEASE; RECEPTOR MESSENGER-RNA; VASOACTIVE INTESTINAL POLYPEPTIDE; ARGININE-VASOPRESSIN; AUTOSOMAL-DOMINANT; V-2; RECEPTOR; SEX-DIFFERENCES; V2; MOLECULAR-CLONING; V-1A RECEPTOR;

D O I：

10.3390/biomedicines9010089

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Vasopressins are evolutionarily conserved peptide hormones. Mammalian vasopressin functions systemically as an antidiuretic and regulator of blood and cardiac flow essential for adapting to terrestrial environments. Moreover, vasopressin acts centrally as a neurohormone involved in social and parental behavior and stress response. Vasopressin synthesis in several cell types, storage in intracellular vesicles, and release in response to physiological stimuli are highly regulated and mediated by three distinct G protein coupled receptors. Other receptors may bind or cross-bind vasopressin. Vasopressin is regulated spatially and temporally through transcriptional and post-transcriptional mechanisms, sex, tissue, and cell-specific receptor expression. Anomalies of vasopressin signaling have been observed in polycystic kidney disease, chronic heart failure, and neuropsychiatric conditions. Growing knowledge of the central biological roles of vasopressin has enabled pharmacological advances to treat these conditions by targeting defective systemic or central pathways utilizing specific agonists and antagonists.

引用

页码：1 / 32

页数：32

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