A phototherapeutic fluorescent β-cyclodextrin branched polymer delivering nitric oxide

被引：32
|
作者：
Malanga, Milo [2 ]
Seggio, Mimimorena [1 ]
Kirejev, Vladimir [3 ]
Fraix, Aurore [1 ]
Di Bari, Ivana [1 ]
Fenyvesi, Eva [2 ]
Ericson, Marica B. [3 ]
Sortino, Salvatore [1 ]
机构：
[1] Univ Catania, Lab Photochem, Dept Drug Sci, I-95125 Catania, Italy
[2] CycloLab Ltd, Illatos Ut 7, H-1097 Budapest, Hungary
[3] Univ Gothenburg, Dept Chem & Mol Biol, Biomed Photon Grp, Kemivagen 10, SE-41296 Gothenburg, Sweden
来源：
BIOMATERIALS SCIENCE | 2019年 / 7卷 / 06期
基金：
瑞典研究理事会;
关键词：
DUAL-COLOR FLUORESCENCE; PHOTODYNAMIC THERAPY; RELEASE; FLUTAMIDE; VESICLES; NO;
D O I：
10.1039/c9bm00395a
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
We report herein on a novel water-soluble beta-cyclodextrin-branched polymer covalently integrating a fluorescein moiety and a nitric oxide (NO) photodonor within its macromolecular skeleton. Photoexcitation with visible light induces the parallel activation of the two chromophores, which results in the green fluorescence emission suitable for imaging accompanied by NO release for therapy. In fact, this polymer internalizes in squamous carcinoma cancer cells in vitro, visualized by fluorescence microscopy, and induces cell mortality as result of the NO photo-decaging. The non-covalent drug delivery capability of this new material is also demonstrated using a hydrophobic photosensitizer for photodynamic therapy as a probe.
引用
收藏
页码：2272 / 2276
页数：5
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