Kinetics of Pertussis Immune Responses to Tetanus-Diphtheria-Acellular Pertussis Vaccine in Health Care Personnel: Implications for Outbreak Control

被引：18

作者：

Kirkland, Kathryn B. ^{[1
]}

Talbot, Elizabeth A.

Decker, Michael D. ^{[2
,3
]}

Edwards, Kathryn M. ^{[4
]}

机构：

[1] Dartmouth Hitchcock Med Ctr, Sect Infect Dis & Int Hlth, Dept Med, Lebanon, NH 03756 USA

[2] Sanofi Pasteur, Swiftwater, PA USA

[3] Vanderbilt Univ, Sch Med, Dept Prevent Med, Nashville, TN 37212 USA

[4] Vanderbilt Univ, Sch Med, Dept Pediat, Nashville, TN 37212 USA

来源：

CLINICAL INFECTIOUS DISEASES | 2009年 / 49卷 / 04期

关键词：

NOSOCOMIAL PERTUSSIS; COSTS;

D O I：

10.1086/603555

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We assessed the kinetics of the humoral immune response to pertussis antigens following vaccination of health care personnel with adult tetanus-diphtheria-acellular pertussis vaccine (Tdap). By 2 weeks after vaccination, 88%-94% of subjects demonstrated a booster response. This brisk response of adults to Tdap supports a role for vaccination in pertussis outbreak control.

引用

页码：584 / 587

页数：4

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