Kinetics of Pertussis Immune Responses to Tetanus-Diphtheria-Acellular Pertussis Vaccine in Health Care Personnel: Implications for Outbreak Control

被引：18
|
作者：
Kirkland, Kathryn B. [1 ]
Talbot, Elizabeth A.
Decker, Michael D. [2 ,3 ]
Edwards, Kathryn M. [4 ]
机构：
[1] Dartmouth Hitchcock Med Ctr, Sect Infect Dis & Int Hlth, Dept Med, Lebanon, NH 03756 USA
[2] Sanofi Pasteur, Swiftwater, PA USA
[3] Vanderbilt Univ, Sch Med, Dept Prevent Med, Nashville, TN 37212 USA
[4] Vanderbilt Univ, Sch Med, Dept Pediat, Nashville, TN 37212 USA
来源：
CLINICAL INFECTIOUS DISEASES | 2009年 / 49卷 / 04期
关键词：
NOSOCOMIAL PERTUSSIS; COSTS;
D O I：
10.1086/603555
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We assessed the kinetics of the humoral immune response to pertussis antigens following vaccination of health care personnel with adult tetanus-diphtheria-acellular pertussis vaccine (Tdap). By 2 weeks after vaccination, 88%-94% of subjects demonstrated a booster response. This brisk response of adults to Tdap supports a role for vaccination in pertussis outbreak control.
引用
收藏
页码：584 / 587
页数：4
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