Cortical Hemodynamic Responses Under Focused Ultrasound Stimulation Using Real-Time Laser Speckle Contrast Imaging

被引：15
|
作者：
Yuan, Yi [1 ]
Zhao, Yanchao [1 ]
Jia, Hongshuai [2 ]
Liu, Mengyang [3 ]
Hui, Shuo [1 ]
Li, Yingwei [4 ]
Li, Xiaoli [5 ,6 ]
机构：
[1] Yanshan Univ, Inst Elect Engn, Qihhuanadao, Peoples R China
[2] North Chiha Univ Sci & Technol, Sch Clin Med, Tangshan, Peoples R China
[3] Med Univ Vienna, Ctr Med Phys & Biomed Engn, Vienna, Austria
[4] Yanshan Univ, Inst Informat Engn, Qinhuangdao, Peoples R China
[5] Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing, Peoples R China
[6] Beijing Normal Univ, McGovern Inst Brain Res, IDG, Beijing, Peoples R China
来源：
FRONTIERS IN NEUROSCIENCE | 2018年 / 12卷
基金：
中国国家自然科学基金;
关键词：
focused ultrasound stimulation; laser speckle contrast imaging; cerebral blood flow; rat; real-time; PRIMARY SOMATOSENSORY CORTEX; BLOOD-FLOW; FUNCTIONAL ACTIVATION; BRAIN-INJURY; MODEL;
D O I：
10.3389/fnins.2018.00269
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Although there is increasing use of focused ultrasound stimulation (FUS) in brain studies, the real-time changes of the cerebral blood flow (CBF) due to FUS remain unclear. In this study, we developed a novel scheme combining FUS and laser speckle contrast imaging, which can be used to measure the CBF caused by FUS in real time. The results showed that the change of CBF increased from 0 to 30 s and reached up to the maximum of 115.1 +/- 6.5% at 30 s and then decreased gradually from 30 to 60 s. This study demonstrates that FUS was able to increase CBF and alter cortical hemodynamic responses, which indicates that FUS is a potential non-invasive method to study ischemic stroke rehabilitation.
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页数：8
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