Pigs are not susceptible to SARS-CoV-2 infection but are a model for viral immunogenicity studies

被引：41

作者：

Vergara-Alert, Julia ^{[1
,2
]}

Rodon, Jordi ^{[1
]}

Carrillo, Jorge ^{[3
]}

Te, Nigeer ^{[1
]}

Izquierdo-Useros, Nuria ^{[3
,4
]}

Rodriguez de la Concepcion, Maria Luisa ^{[3
]}

Avila-Nieto, Carlos ^{[3
]}

Guallar, Victor ^{[5
,6
]}

Valencia, Alfonso ^{[5
,6
]}

Cantero, Guillermo ^{[1
]}

Blanco, Julia ^{[3
,4
,7
]}

Clotet, Bonaventura ^{[3
,4
,7
]}

Bensaid, Albert ^{[1
,2
]}

Segales, Joaquim ^{[2
,8
,9
]}

机构：

[1] IRTA UAB, IRTA, Ctr Recerca Sanitat Anim CReSA, Campus Univ Autonoma Barcelona, Barcelona, Spain

[2] OIE Collaborating Ctr Res & Control Emerging & Re, Barcelona, Spain

[3] IrsiCaixa AIDS Res Inst, Badalona, Spain

[4] Germans Trias & Pujol Res Inst IGTP, Badalona, Spain

[5] Barcelona Supercomp Ctr BSC, Barcelona, Spain

[6] Catalan Inst Res & Adv Studies ICREA, Barcelona, Spain

[7] Cent Univ Catalonia UVic UCC, Univ Vic, Vic, Spain

[8] UAB, IRTA UAB, Ctr Recerca Sanitat Anim CReSA, Campus Univ Autonoma Barcelona, Barcelona, Spain

[9] UAB, Fac Vet, Dept Sanitat & Anat Anim, Barcelona, Spain

来源：

TRANSBOUNDARY AND EMERGING DISEASES | 2021年 / 68卷 / 04期

关键词：

immunogenicity model; inoculation routes; lack of susceptibility; pig; SARS-CoV-2; TRANSMISSION; MERS;

D O I：

10.1111/tbed.13861

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Conventional piglets were inoculated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) through different routes, including intranasal, intratracheal, intramuscular and intravenous ones. Although piglets were not susceptible to SARS-CoV-2 and lacked lesions or viral RNA in tissues/swabs, seroconversion was observed in pigs inoculated parenterally (intramuscularly or intravenously).

引用

页码：1721 / 1725

页数：5

共 50 条

[21] Review of studies on SARS-CoV-2 infection inhibitors
Michalski, Aleksander
Wojcicka, Patrycja
Bielawska-Drozd, Agata
Bartoszcze, Michal
[J]. ANNALS OF AGRICULTURAL AND ENVIRONMENTAL MEDICINE, 2021, 28 (04) : 541 - 550
[22] Spatially distributed infection increases viral load in a computational model of SARS-CoV-2 lung infection
Moses, Melanie
Hofmeyr, Steven
Cannon, Judy
Andrews, Akil J.
Gridley, Rebekah
Hinga, Monica J.
Leyba, Kirtus
Pribisova, Abigail J.
Surjadidjaja, Vanessa
Tasnim, Humayra J.
Forrest, Stephanie
[J]. PLOS COMPUTATIONAL BIOLOGY, 2021, 17 (12)
[23] Immunogenicity of SARS-CoV-2 vaccines in with cancer
Kakkassery, Helen
Carpenter, Esme
Patten, Piers E. M.
Irshad, Sheeba
[J]. TRENDS IN MOLECULAR MEDICINE, 2022, 28 (12) : 1082 - 1099
[24] Immunogenicity of SARS-CoV-2 Vaccine in Dialysis
Lacson, Eduardo, Jr.
Argyropoulos, Christos P.
Manley, Harold J.
Aweh, Gideon
Chin, Andrew I.
Salman, Loay H.
Hsu, Caroline M.
Johnson, Doug S.
Weiner, Daniel E.
[J]. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2021, 32 (11): : 2735 - 2742
[25] Little Brown Bats (Myotis lucifugus) Support the Binding of SARS-CoV-2 Spike and Are Likely Susceptible to SARS-CoV-2 Infection
Chothe, Shubhada K.
Jakka, Padmaja
Boorla, Veda Sheersh
Ramasamy, Santhamani
Gontu, Abhinay
Nissly, Ruth H.
Brown, Justin
Turner, Gregory
Sewall, Brent J.
Reeder, DeeAnn M.
Field, Kenneth A.
Engiles, Julie B.
Amirthalingam, Saranya
Ravichandran, Abirami
LaBella, Lindsey
Nair, Meera Surendran
Maranas, Costas D.
Kuchipudi, Suresh V.
[J]. VIRUSES-BASEL, 2023, 15 (05):
[26] Common Laboratory Mice Are Susceptible to Infection with the SARS-CoV-2 Beta Variant
Kant, Ravi
Kareinen, Lauri
Smura, Teemu
Freitag, Tobias L.
Jha, Sawan Kumar
Alitalo, Kari
Meri, Seppo
Sironen, Tarja
Saksela, Kalle
Strandin, Tomas
Kipar, Anja
Vapalahti, Olli
[J]. VIRUSES-BASEL, 2021, 13 (11):
[27] The Upper Respiratory Tract of Felids Is Highly Susceptible to SARS-CoV-2 Infection
Krueger, Nadine
Rocha, Cheila
Runft, Sandra
Krueger, Johannes
Faerber, Iris
Armando, Federico
Leitzen, Eva
Brogden, Graham
Gerold, Gisa
Poehlmann, Stefan
Hoffmann, Markus
Baumgaertner, Wolfgang
[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (19)
[28] Human iPSC-Derived Cardiomyocytes Are Susceptible to SARS-CoV-2 Infection
Sharma, Arun
Garcia, Gustavo
Wang, Yizhou
Plummer, Jasmine T.
Morizono, Kouki
Arumugaswami, Vaithilingaraja
Svendsen, Clive N.
[J]. CELL REPORTS MEDICINE, 2020, 1 (04)
[29] Weathering the Cytokine Storm in Susceptible Patients with Severe SARS-CoV-2 Infection
Lipworth, Brian
Chan, Rory
Lipworth, Samuel
Kuo, Chris RuiWen
[J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 2020, 8 (06): : 1798 - 1801
[30] Association between Gut Microbiota and SARS-CoV-2 Infection and Vaccine Immunogenicity
Ng, Ho Yu
Leung, Wai K.
Cheung, Ka Shing
[J]. MICROORGANISMS, 2023, 11 (02)

← 1 2 3 4 5 →