Pigs are not susceptible to SARS-CoV-2 infection but are a model for viral immunogenicity studies

被引：41

作者：

Vergara-Alert, Julia ^{[1
,2
]}

Rodon, Jordi ^{[1
]}

Carrillo, Jorge ^{[3
]}

Te, Nigeer ^{[1
]}

Izquierdo-Useros, Nuria ^{[3
,4
]}

Rodriguez de la Concepcion, Maria Luisa ^{[3
]}

Avila-Nieto, Carlos ^{[3
]}

Guallar, Victor ^{[5
,6
]}

Valencia, Alfonso ^{[5
,6
]}

Cantero, Guillermo ^{[1
]}

Blanco, Julia ^{[3
,4
,7
]}

Clotet, Bonaventura ^{[3
,4
,7
]}

Bensaid, Albert ^{[1
,2
]}

Segales, Joaquim ^{[2
,8
,9
]}

机构：

[1] IRTA UAB, IRTA, Ctr Recerca Sanitat Anim CReSA, Campus Univ Autonoma Barcelona, Barcelona, Spain

[2] OIE Collaborating Ctr Res & Control Emerging & Re, Barcelona, Spain

[3] IrsiCaixa AIDS Res Inst, Badalona, Spain

[4] Germans Trias & Pujol Res Inst IGTP, Badalona, Spain

[5] Barcelona Supercomp Ctr BSC, Barcelona, Spain

[6] Catalan Inst Res & Adv Studies ICREA, Barcelona, Spain

[7] Cent Univ Catalonia UVic UCC, Univ Vic, Vic, Spain

[8] UAB, IRTA UAB, Ctr Recerca Sanitat Anim CReSA, Campus Univ Autonoma Barcelona, Barcelona, Spain

[9] UAB, Fac Vet, Dept Sanitat & Anat Anim, Barcelona, Spain

来源：

TRANSBOUNDARY AND EMERGING DISEASES | 2021年 / 68卷 / 04期

关键词：

immunogenicity model; inoculation routes; lack of susceptibility; pig; SARS-CoV-2; TRANSMISSION; MERS;

D O I：

10.1111/tbed.13861

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Conventional piglets were inoculated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) through different routes, including intranasal, intratracheal, intramuscular and intravenous ones. Although piglets were not susceptible to SARS-CoV-2 and lacked lesions or viral RNA in tissues/swabs, seroconversion was observed in pigs inoculated parenterally (intramuscularly or intravenously).

引用

页码：1721 / 1725

页数：5

共 50 条

[1] Three-Week Old Pigs Are Not Susceptible to Productive Infection with SARS-COV-2
Haddock, Elaine
Callison, Julie
Seifert, Stephanie N.
Okumura, Atsushi
Tang-Huau, Tsing-Lee
Leventhal, Shanna S.
Lewis, Matthew C.
Lovaglio, Jamie
Hanley, Patrick W.
Shaia, Carl
Hawman, David W.
Munster, Vincent J.
Jarvis, Michael A.
Richt, Juergen A.
Feldmann, Heinz
[J]. MICROORGANISMS, 2022, 10 (02)
[2] Human Cardiac Pericytes Are Susceptible to SARS-CoV-2 Infection
Brumback, Brittany D.
Dmytrenko, Oleksandr
Robinson, Ashley N.
Bailey, Adam L.
Ma, Pan
Liu, Jing
Hicks, Stephanie C.
Ng, Sherwin
Li, Gang
Zhang, David M.
Lipovsky, Catherine E.
Lin, Chieh-Yu
Diamond, Michael S.
Lavine, Kory J.
Rentschler, Stacey L.
[J]. JACC-BASIC TO TRANSLATIONAL SCIENCE, 2023, 8 (02): : 109 - 120
[3] Human Aged Cardiomyocytes Are Susceptible to SARS-CoV-2 Infection
Lazzarini, Edoardo
Marcandalli, Jessica
Lodrini, Alessandra M.
Biemmi, Vanessa
Balbi, Carolina
Bolis, Sara
Altomare, Claudia
Vassalli, Giuseppe
Bollini, Sveva
Rocchetti, Marcella
Perez, Laurent
Barile, Lucio
[J]. CIRCULATION RESEARCH, 2020, 127 (12) : E273 - E274
[4] Are moto-neurons susceptible to SARS-CoV-2 infection?
Cappelletti, G.
Colombrita, C.
Limanaqi, F.
Strizzi, S.
Vanetti, C.
Garziano, M.
Trabattoni, D.
Santangelo, S.
Silani, V.
Ratti, A.
Biasin, M.
[J]. JOURNAL OF THE INTERNATIONAL AIDS SOCIETY, 2023, 26
[5] Viral Cardiomyopathies Associated With SARS-CoV-2 Infection
Almanza-Hurtado, Amilkar
Cristina Martinez-Avila, Maria
Rodriguez-Yanez, Tomas
Carolina Paternina-Mendoza, Maria
Camilo Gutierrez-Ariza, Juan
Gomez-Arroyo, Gino
[J]. CLINICAL MEDICINE INSIGHTS-CASE REPORTS, 2022, 15
[6] Viral Cardiomyopathies Associated With SARS-CoV-2 Infection
Almanza-Hurtado, Amilkar
Cristina Martinez-Avila, Maria
Rodriguez-Yanez, Tomas
Carolina Paternina-Mendoza, Maria
Camilo Gutierrez-Ariza, Juan
Gomez-Arroyo, Gino
[J]. CLINICAL MEDICINE INSIGHTS-CASE REPORTS, 2022, 15
[7] Modeling the viral dynamics of SARS-CoV-2 infection
Wang, Sunpeng
Pan, Yang
Wang, Quanyi
Miao, Hongyu
Brown, Ashley N.
Rong, Libin
[J]. MATHEMATICAL BIOSCIENCES, 2020, 328
[8] Defining the Syrian hamster as a highly susceptible preclinical model for SARS-CoV-2 infection
Rosenke, Kyle
Meade-White, Kimberly
Letko, Michael
Clancy, Chad
Hansen, Frederick
Liu, Yanan
Okumura, Atsushi
Tang-Huau, Tsing-Lee
Li, Rong
Saturday, Greg
Feldmann, Friederike
Scott, Dana
Wang, Zhongde
Munster, Vincent
Jarvis, Michael A.
Feldmann, Heinz
[J]. EMERGING MICROBES & INFECTIONS, 2020, 9 (01) : 2673 - 2684
[9] SARS-CoV-2 immunogenicity at the crossroads
Karamloo, Fariba
Koenig, Renate
[J]. ALLERGY, 2020, 75 (07) : 1822 - 1824
[10] An ace model for SARS-CoV-2 infection
Major, Jack
Wack, Andreas
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2020, 217 (12):

← 1 2 3 4 5 →