共 50 条
A dramatic enhancing effect of InBr3 towards the oxidative Sonogashira cross-coupling reaction of 2-ethynylanilines
被引：11
|作者：
Ikeda, A.
[1
]
Omote, M.
[1
]
Kusumoto, K.
[1
]
Komori, M.
[1
]
Tarui, A.
[1
]
Sato, K.
[1
]
Ando, A.
[1
]
机构：
[1] Setsunan Univ, Fac Pharmaceut Sci, 45-1 Nagaotoge Cho, Hirakata, Osaka 5730101, Japan
关键词：
ONE-POT SYNTHESIS;
COPPER-FREE;
TERMINAL ALKYNES;
AMINE-FREE;
INDOLE ALKALOIDS;
ARYL BROMIDES;
EFFICIENT;
CATALYST;
HALIDES;
CARBON;
D O I：
10.1039/c5ob02558c
中图分类号：
O62 [有机化学];
学科分类号：
070303 ;
081704 ;
摘要：
The addition of InBr3 to the oxidative Sonogashira cross-coupling reaction of 2-ethynylaniline with (E)-trimethyl(3,3,3-trifluoroprop-1-enyl)silane led to a dramatic increase in the reactivity to afford the corresponding 1,3-enynes bearing a trifluoromethyl group on their terminal sp(2) carbon. The subsequent cyclization of these 1,3-enynes under palladium catalysis provides access to the corresponding indoles bearing a 3,3,3-trifluoroprop-1-enyl group at their 2-position.
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页码：2127 / 2133
页数：7
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