T-cell memory: lessons from Epstein-Barr virus infection in man

被引:24
|
作者
Rickinson, AB [1 ]
Callan, MFC
Annels, NE
机构
[1] Univ Birmingham, CRC, Inst Canc Studies, Birmingham B15 2TT, W Midlands, England
[2] John Radcliffe Hosp, Inst Mol Med, Oxford OX3 9DU, England
关键词
T-cell memory; Epstein-Barr virus; cytotoxic T cells; infectious mononucleosis; primary infection; persistent infection;
D O I
10.1098/rstb.2000.0579
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Epstein-Barr virus offers an ideal opportunity to follow the human T-cell response to a virus infection over time from its acute primary phase, as seen in infectious mononucleosis patients, into the memory phase that accompanies life-long virus persistence. Here we review recent evidence on the development and maturation of cytotoxic T-cell memory using this viral system.
引用
收藏
页码:391 / 400
页数:10
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