T-cell memory: lessons from Epstein-Barr virus infection in man

被引：24

作者：

Rickinson, AB ^{[1
]}

Callan, MFC

Annels, NE

机构：

[1] Univ Birmingham, CRC, Inst Canc Studies, Birmingham B15 2TT, W Midlands, England

[2] John Radcliffe Hosp, Inst Mol Med, Oxford OX3 9DU, England

来源：

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES | 2000年 / 355卷 / 1395期

关键词：

T-cell memory; Epstein-Barr virus; cytotoxic T cells; infectious mononucleosis; primary infection; persistent infection;

D O I：

10.1098/rstb.2000.0579

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Epstein-Barr virus offers an ideal opportunity to follow the human T-cell response to a virus infection over time from its acute primary phase, as seen in infectious mononucleosis patients, into the memory phase that accompanies life-long virus persistence. Here we review recent evidence on the development and maturation of cytotoxic T-cell memory using this viral system.

引用

页码：391 / 400

页数：10

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