Anti-tubulins DEPendably induce apoptosis

被引：10
|
作者：
Denning, Daniel P. [1 ]
Hirose, Takashi [1 ]
机构：
[1] MIT, Howard Hughes Med Inst, Dept Biol, Cambridge, MA 02139 USA
来源：
NATURE CELL BIOLOGY | 2014年 / 16卷 / 08期
关键词：
LET-99; MICROTUBULES; TARGET; DRUGS; MCL1;
D O I：
10.1038/ncb3012
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Anti-tubulin drugs are life-saving chemotherapeutics that kill cancer cells by stabilizing or disrupting microtubules. Despite their clinical utility, the molecular mechanisms by which anti-tubulins cause apoptotic cell death remain poorly understood. It is now shown that microtubule disruption can inhibit anti-apoptotic Bcl-2 family proteins through an evolutionarily conserved signalling axis involving DEPDC1 (LET-99 in Caenorhabditis elegans) and JNK.
引用
收藏
页码：741 / 743
页数：4
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