Tagraxofusp, an Anti-CD123 Therapy, in Patients With Blastic Plasmacytoid Dendritic Cell Neoplasm: Sub-Analysis of a Pivotal Trial by Age and Baseline Disease Involvement

被引：0

作者：

Pemmaraju, Naveen ^{[1
]}

Konopleva, Marina ^{[1
]}

Sweet, Kendra ^{[2
]}

Stein, Anthony ^{[3
]}

Vasu, Sumithira ^{[4
]}

Rizzieri, David ^{[5
]}

Wang, Eunice S. ^{[6
]}

Kantarjian, Hagop ^{[1
]}

Brooks, Chris ^{[7
]}

Mughal, Tariq ^{[7
]}

Lane, Andrew ^{[8
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Houston, TX USA

[2] H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL USA

[3] City Hope Natl Med Ctr, Duarte, CA USA

[4] Ohio State Univ, Columbus, OH USA

[5] Duke Univ, Med Ctr, Durham, NC USA

[6] Roswell Pk Comprehens Canc Ctr, Buffalo, NY USA

[7] Stemline Therapeut Inc, New York, NY USA

[8] Dana Farber Canc Inst, Boston, MA USA

来源：

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA | 2022年 / 22卷

关键词：

AML; myeloid neoplasm; targeted therapy; CD123; tagraxofusp; BPDCN; Phase I/II;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

AML-465

引用

页码：S254 / S254

页数：1

共 42 条

[31] CD38 and BCL2 expression guides treatment with daratumumab and venetoclax in tagraxofusp-refractory blastic plasmacytoid dendritic cell neoplasm (BPDCN) featuring dynamic loss of CD123
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[32] Apparent partial loss of CD123 expression in blastic plasmacytoid dendritic cell neoplasm after treatment with CD123-targeted therapy: A novel finding and possible diagnostic pitfall
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Prieto, Victor G.
JOURNAL OF DERMATOLOGY, 2020, 47 (10): : E354 - E355
[33] CD123-directed allogeneic chimeric-antigen receptor T-cell therapy (CAR-T) in blastic plasmacytoid dendritic cell neoplasm (BPDCN): Clinicopathological insights
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LEUKEMIA RESEARCH, 2022, 121
[34] Experience with IMGN632, a Novel CD123-Targeting Antibody-Drug Conjugate (ADC), in Frontline Patients with Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)
Pemmaraju, Naveen
Martinelli, Giovanni
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Sweet, Kendra
Rizzieri, David A.
Marconi, Giovanni
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DeAngelo, Daniel J.
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Erba, Harry P.
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Levy, Moshe Y.
Sloss, Callum M.
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BLOOD, 2021, 138
[35] Remissions of Acute Myeloid Leukemia and Blastic Plasmacytoid Dendritic Cell Neoplasm Following Treatment with CD123-Specific CAR T Cells: A First-inHuman Clinical Trial
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Blanchard, Suzette
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Marcucci, Emanuela
Shepphird, Jennifer K.
Wang, Xiuli
Wood, Brent
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[36] A Study of IMGN632, a Novel CD123-Targeting Antibody-Drug Conjugate, for Patients with Frontline and Relapsed/Refractory Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)
Pemmaraju, Naveen
Marconi, Giovanni
Todisco, Elisabetta
Montesinos, Pau
Lane, Andrew A.
Sweet, Kendra
Wang, Eunice S.
Deconinck, Eric
Rizzieri, David A.
Walter, Roland B.
Aribi, Ahmed
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Levy, Moshe Y.
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Erba, Harry P.
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BLOOD, 2021, 138
[37] Clinical Profile of IMGN632, a Novel CD123-Targeting Antibody-Drug Conjugate (ADC), in Patients with Relapsed/Refractory (R/R) Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)
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Martinelli, Giovanni
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Lane, Andrew A.
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Wang, Eunice S.
Sweet, Kendra L.
Rizzieri, David A.
Mazzarella, Luca
DeAngelo, Daniel J.
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Tarella, Corrado
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[38] Efficacy Proof of Concept for Allogeneic CD123 Targeting CAR T-Cells Against Primary Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN): Efficient Control of Tumor Progression in PDX Model and Potential Loss of CD123 Expression in Relapsed Disease
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Black, Kathryn L.
Naqvi, Ammar S.
Taylor, Deanne
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Gouble, Agnes
Smith, Julianne N. P.
Cavazos, Antonio
Han, Lina
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Ma, Helen
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[39] A phase I/II study of IMGN632, a novel CD123-targeting antibody-drug conjugate, in patients with relapsed/refractory acute myeloid leukemia, blastic plasmacytoid dendritic cell neoplasm, and other CD123-positive hematologic malignancies.
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Wang, Eunice S.
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JOURNAL OF CLINICAL ONCOLOGY, 2020, 38 (15)
[40] Lead-in Stage Results of a Pivotal Trial of SL-401, an Interleukin-3 Receptor (IL-3R) Targeting Biologic, in Patients with Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) or Acute Myeloid Leukemia (AML)
Sweet, Kendra L.
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Lane, Andrew A.
Stein, Anthony S.
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Rowinsky, Eric K.
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BLOOD, 2015, 126 (23)

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