Review of pneumococcal conjugate vaccine in adults: implications on clinical development

被引：31

作者：

Abraham-Van Parijs, B

机构：

[1] GlaxoSmithKline, Clin Dev & Med Affairs N America, Antiinfect, Collegeville, PA 19460 USA

[2] Wyeth Pharmaceut, Global Med Affairs Vaccines, Collegeville, PA 19426 USA

来源：

VACCINE | 2004年 / 22卷 / 11-12期

关键词：

pneumococcal; conjugate vaccine; adults;

D O I：

10.1016/j.vaccine.2004.01.029

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A literature review was conducted to determine if pneumococcal conjugate vaccines administered to healthy and immunocompromised adults, in comparison with the known efficacy in children, showed immunogenicity. Fifteen publications were retrieved. Clinical studies had been conducted using vaccines from different manufacturers, in different populations, using varied methodologies. No clear evidence of the superiority of the conjugate vaccine over the currently licensed polysaccharide vaccine emerged. Possible reasons for the lack of superiority and its implications on vaccine development are discussed. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：1362 / 1371

页数：10

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