A Novel Live-Attenuated Vaccine Candidate for Mayaro Fever

被引：48
|
作者：
Weise, William J. [1 ]
Hermance, Meghan E.
Forrester, Naomi
Adams, A. Paige
Langsjoen, Rose
Gorchakov, Rodion
Wang, Eryu
Alcorn, Maria D. H.
Tsetsarkin, Konstantin
Weaver, Scott C.
机构：
[1] Univ Texas Med Branch, Inst Human Infect & Immun, Ctr Trop Dis, Galveston, TX 77555 USA
来源：
PLOS NEGLECTED TROPICAL DISEASES | 2014年 / 8卷 / 08期
基金：
美国国家卫生研究院;
关键词：
EQUINE ENCEPHALITIS-VIRUS; CHIKUNGUNYA VIRUS; CYNOMOLGUS MACAQUES; ENCEPHALOMYELITIS VIRUS; NONHUMAN-PRIMATES; AMAZON BASIN; INFECTION; DISEASE; STRAIN; ALPHAVIRUSES;
D O I：
10.1371/journal.pntd.0002969
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Mayaro virus (MAYV) is an emerging, mosquito-borne alphavirus that causes a dengue-like illness in many regions of South America, and which has the potential to urbanize. Because no specific treatment or vaccine is available for MAYV infection, we capitalized on an IRES-based approach to develop a live-attenuated MAYV vaccine candidate. Testing in infant, immunocompetent as well as interferon receptor-deficient mice demonstrated a high degree of attenuation, strong induction of neutralizing antibodies, and efficacy against lethal challenge. This vaccine strain was also unable to infect mosquito cells, a major safety feature for a live vaccine derived from a mosquito-borne virus. Further preclinical development of this vaccine candidate is warranted to protect against this important emerging disease.
引用
收藏
页数：9
相关论文
共 50 条
  • [21] A live-attenuated Zika virus vaccine candidate induces sterilizing immunity in mouse models
    Shan, Chao
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2017, 254
  • [22] A live-attenuated SARS-CoV-2 vaccine candidate with accessory protein deletions
    Liu, Yang
    Zhang, Xianwen
    Liu, Jianying
    Xia, Hongjie
    Zou, Jing
    Muruato, Antonio E.
    Periasamy, Sivakumar
    Plante, Jessica A.
    Bopp, Nathen E.
    Kalveram, Birte
    Kurhade, Chaitanya
    Bukreyev, Alexander
    Ren, Ping
    Wang, Tian
    Menachery, Vineet D.
    Plante, Kenneth S.
    Xie, Xuping
    Weaver, Scott C.
    Shi, Pei-Yong
    NATURE COMMUNICATIONS, 2022, 13 (01)
  • [23] Development of a live-attenuated influenza B ΔNS1 intranasal vaccine candidate
    Wressnigg, Nina
    Voss, Daniel
    Wolff, Thorsten
    Romanova, Julia
    Ruthsatz, Tanja
    Mayerhofer, Ines
    Reiter, Manfred
    Nakowitsch, Sabine
    Humer, Johannes
    Morokutti, Alexander
    Muster, Thomas
    Egorov, Andrej
    Kittel, Christian
    VACCINE, 2009, 27 (21) : 2851 - 2857
  • [24] Replication Kinetics of a Candidate Live-Attenuated Vaccine for Cache Valley Virus in Aedes albopictus
    Ayers, Victoria B.
    Huang, Yan-Jang S.
    Dunlop, James I.
    Kohl, Alain
    Brennan, Benjamin
    Higgs, Stephen
    Vanlandingham, Dana L.
    VECTOR-BORNE AND ZOONOTIC DISEASES, 2022, 22 (11) : 553 - 558
  • [25] A live-attenuated Zika virus vaccine candidate induces sterilizing immunity in mouse models
    Chao Shan
    Antonio E Muruato
    Bruno T D Nunes
    Huanle Luo
    Xuping Xie
    Daniele B A Medeiros
    Maki Wakamiya
    Robert B Tesh
    Alan D Barrett
    Tian Wang
    Scott C Weaver
    Pedro F C Vasconcelos
    Shannan L Rossi
    Pei-Yong Shi
    Nature Medicine, 2017, 23 : 763 - 767
  • [26] Live-attenuated bacteria as a cancer vaccine vector
    Toussaint, Bertrand
    Chauchet, Xavier
    Wang, Yan
    Polack, Benoit
    Le Gouellec, Audrey
    EXPERT REVIEW OF VACCINES, 2013, 12 (10) : 1139 - 1154
  • [27] A Lassa Fever Live-Attenuated Vaccine Based on Codon Deoptimization of the Viral Glycoprotein Gene
    Cai, Yingyun
    Ye, Chengjin
    Cheng, Benson
    Nogales, Aitor
    Iwasaki, Masaharu
    Yu, Shuiqing
    Cooper, Kurt
    Liu, David X.
    Hart, Randy
    Adams, Ricky
    Brady, Tyler
    Postnikova, Elena N.
    Kurtz, Jonathan
    St Claire, Marisa
    Kuhn, Jens H.
    de la Torre, Juan Carlos
    Martinez-Sobrido, Luis
    MBIO, 2020, 11 (01):
  • [28] Safety, efficacy, and DIVA feasibility on a novel live attenuated classical swine fever marker vaccine candidate
    Tong, Chao
    Liu, Huanhuan
    Wang, Jiaying
    Sun, Yanyong
    Chen, Ning
    VACCINE, 2022, 40 (50) : 7219 - 7229
  • [29] Safety and immunogenicity of a live-attenuated auxotrophic candidate vaccine against the intracellular pathogen Rhodococcus equi
    Lopez, A. M.
    Townsend, H. G. G.
    Allen, A. L.
    Hondalus, M. K.
    VACCINE, 2008, 26 (07) : 998 - 1009
  • [30] SAFETY AND IMMUNOGENICITY OF A LIVE-ATTENUATED JUNIN (ARGENTINE HEMORRHAGIC-FEVER) VACCINE IN RHESUS MACAQUES
    MCKEE, KT
    ORO, JGB
    KUEHNE, AI
    SPISSO, JA
    MAHLANDT, BG
    AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1993, 48 (03): : 403 - 411
12345