Iron on the move: mobilizing liver iron via NCOA4

被引：13
|
作者：
Philpott, Caroline C. [1 ]
机构：
[1] NIDDK, Bethesda, MD 26506 USA
来源：
BLOOD | 2020年 / 136卷 / 23期
关键词：
FERRITIN; HOMEOSTASIS; STORAGE; PCBP1;
D O I：
10.1182/blood.2020007971
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In this issue of Blood, Li et al(1) have demonstrated that NCOA4, the autophagic receptor for ferritin, is necessary for the mobilization of liver iron stores during stress erythropoiesis in mice.
引用
收藏
页码：2604 / 2605
页数：3
相关论文
共 50 条
  • [11] PCBP1 and NCOA4 regulate erythroid iron storage and heme biosynthesis
    Ryu, Moon-Suhn
    Zhang, Deliang
    Protchenko, Olga
    Shakoury-Elizeh, Minoo
    Philpott, Caroline C.
    JOURNAL OF CLINICAL INVESTIGATION, 2017, 127 (05): : 1786 - 1797
  • [12] NCOA4 Acts in Hepatocytes to Regulate Ferritin Subunit Levels and Hepatic Iron Storage
    Sukumaran, Abitha
    Lozovatsky, Larisa
    Li, Xiuqi
    Gonzalez, Luis A.
    Cao, Chang
    Fleming, Mark D.
    Finberg, Karin E.
    BLOOD, 2017, 130
  • [13] Ferritin iron regulators, PCBP1 and NCOA4, respond to cellular iron status in developing red cells
    Ryu, Moon-Suhn
    Duck, Kari A.
    Philpott, Caroline C.
    BLOOD CELLS MOLECULES AND DISEASES, 2018, 69 : 75 - 81
  • [14] NCOA4 INCREASES IN CONDITION OF MODERATE IRON OVERLOAD BUT NOT IN HIGLY IRON OVERLOADED MICE AND IN TFR2 KO ANIMALS
    Pellegrino, Rosa Maria
    Boero, Martina
    Palmieri, Antonietta
    Mezzanotte, Mariarosa
    Saglio, Giuseppe
    Roetto, Antonella
    AMERICAN JOURNAL OF HEMATOLOGY, 2017, 92 (08) : E253 - E253
  • [15] Pcbp1 and Ncoa4 Regulate the Flux of Iron through Ferritin in Developing Erythroid Cells
    Ryu, Moon-Suhn
    Wohlschlegel, James
    Philpott, Caroline C.
    BLOOD, 2015, 126 (23)
  • [16] NCOA4 is regulated by HIF and mediates mobilization of murine hepatic iron stores after blood loss
    Li, Xiuqi
    Lozovatsky, Larisa
    Sukumaran, Abitha
    Gonzalez, Luis
    Jain, Anisha
    Liu, Dong
    Ayala-Lopez, Nadia
    Finberg, Karin E.
    BLOOD, 2020, 136 (23) : 2691 - 2702
  • [17] Modulation of the HIF2α-NCOA4 axis in enterocytes attenuates iron loading in a mouse model of hemochromatosis
    Das, Nupur K.
    Jain, Chesta
    Sankar, Amanda
    Schwartz, Andrew J.
    Santana-Codina, Naiara
    Solanki, Sumeet
    Zhang, Zhiguo
    Ma, Xiaoya
    Parimi, Sanjana
    Rui, Liangyou
    Mancias, Joseph D.
    Shah, Yatrik M.
    BLOOD, 2022, 139 (16) : 2547 - 2552
  • [18] A STUDY OF NCOA4 EXPRESSION AND BINDING TO FERRITINS
    Gryzik, Magdalena
    Carmona, Fernando
    Poli, Maura
    Arosio, Paolo
    AMERICAN JOURNAL OF HEMATOLOGY, 2017, 92 (08) : E310 - E310
  • [19] NCOA4: More than a receptor for ferritinophagy
    Wang, Zheng
    Zhang, Hong
    JOURNAL OF CELL BIOLOGY, 2022, 221 (10):
  • [20] Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo
    William E. Dowdle
    Beat Nyfeler
    Jane Nagel
    Robert A. Elling
    Shanming Liu
    Ellen Triantafellow
    Suchithra Menon
    Zuncai Wang
    Ayako Honda
    Gwynn Pardee
    John Cantwell
    Catherine Luu
    Ivan Cornella-Taracido
    Edmund Harrington
    Peter Fekkes
    Hong Lei
    Qing Fang
    Mary Ellen Digan
    Debra Burdick
    Andrew F. Powers
    Stephen B. Helliwell
    Simon D’Aquin
    Julie Bastien
    Henry Wang
    Dmitri Wiederschain
    Jenny Kuerth
    Philip Bergman
    David Schwalb
    Jason Thomas
    Savuth Ugwonali
    Fred Harbinski
    John Tallarico
    Christopher J. Wilson
    Vic E. Myer
    Jeffery A. Porter
    Dirksen E. Bussiere
    Peter M. Finan
    Mark A. Labow
    Xiaohong Mao
    Lawrence G. Hamann
    Brendan D. Manning
    Reginald A. Valdez
    Thomas Nicholson
    Markus Schirle
    Mark S. Knapp
    Erin P. Keaney
    Leon O. Murphy
    Nature Cell Biology, 2014, 16 : 1069 - 1079
12345