Iron on the move: mobilizing liver iron via NCOA4

被引：13
|
作者：
Philpott, Caroline C. [1 ]
机构：
[1] NIDDK, Bethesda, MD 26506 USA
来源：
BLOOD | 2020年 / 136卷 / 23期
关键词：
FERRITIN; HOMEOSTASIS; STORAGE; PCBP1;
D O I：
10.1182/blood.2020007971
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In this issue of Blood, Li et al(1) have demonstrated that NCOA4, the autophagic receptor for ferritin, is necessary for the mobilization of liver iron stores during stress erythropoiesis in mice.
引用
收藏
页码：2604 / 2605
页数：3
相关论文
共 50 条
  • [1] Oxygen modulates iron homeostasis by switching iron sensing of NCOA4
    Kuno, Sota
    Iwai, Kazuhiro
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2023, 299 (05)
  • [2] NCOA4 links iron bioavailability to DNA metabolism
    Federico, Giorgia
    Carrillo, Federica
    Dapporto, Francesca
    Chiariello, Mario
    Santoro, Massimo
    Bellelli, Roberto
    Carlomagno, Francesca
    CELL REPORTS, 2022, 40 (07):
  • [3] NCOA4 Deficiency Impairs Systemic Iron Homeostasis
    Bellelli, Roberto
    Federico, Giorgia
    Matte', Alessandro
    Colecchia, David
    Iolascon, Achille
    Chiariello, Mario
    Santoro, Massimo
    De Franceschi, Lucia
    Carlomagno, Francesca
    CELL REPORTS, 2016, 14 (03): : 411 - 421
  • [4] NCOA4 Links Iron Bioavailability to DNA Metabolism
    Federico, Giorgia
    Bellelli, Roberto
    Nai, Antonella
    Silvestri, Laura
    Camaschella, Clara
    Iolascon, Achille
    Santoro, Massimo
    Carlomagno, Francesca
    BLOOD, 2017, 130
  • [5] Iron-induced NCOA4 condensation regulates ferritin fate and iron homeostasis
    Kuno, Sota
    Fujita, Hiroaki
    Tanaka, Yu-Ki
    Ogra, Yasumitsu
    Iwai, Kazuhiro
    EMBO REPORTS, 2022, 23 (05)
  • [6] Discovery of a NCOA4 Degrader for Labile Iron-Dependent Ferroptosis Inhibition
    Ji, Jian'ai
    Jin, Yuhui
    Ma, Sinan
    Zhu, Yuxuan
    Bi, Xinyu
    You, Qidong
    Jiang, Zhengyu
    JOURNAL OF MEDICINAL CHEMISTRY, 2024, 67 (15) : 12521 - 12533
  • [7] NCOA4 Mediates Mobilization of Hepatic Iron Stores after Blood Loss
    Li, Xiuqi
    Lozovatsky, Larisa
    Liu, Dong
    Ayala-Lopez, Nadia
    Finberg, Karin E.
    BLOOD, 2018, 132
  • [8] NCOA4 requires a [3Fe-4S] to sense and maintain the iron homeostasis
    Zhao H.
    Lu Y.
    Zhang J.
    Sun Z.
    Cheng C.
    Liu Y.
    Wu L.
    Zhang M.
    He W.
    Hao S.
    Li K.
    Journal of Biological Chemistry, 2024, 300 (02)
  • [9] NCOA4 Regulates Iron Recycling and Responds to Hepcidin Activity and Lipopolysaccharide in Macrophages
    Guggisberg, Cole A.
    Kim, Juyoung
    Lee, Jaekwon
    Chen, Xiaoli
    Ryu, Moon-Suhn
    ANTIOXIDANTS, 2022, 11 (10)
  • [10] Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis
    Mancias, Joseph D.
    Vaites, Laura Pontano
    Nissim, Sahar
    Biancur, Douglas E.
    Kim, Andrew J.
    Wang, Xiaoxu
    Liu, Yu
    Goessling, Wolfram
    Kimmelman, Alec C.
    Harper, J. Wade
    ELIFE, 2015, 4
12345