Cellular and Viral Mechanisms of HIV-1 Transmission Mediated by Dendritic Cells

被引：22

作者：

Coleman, Christopher M. ^{[1
]}

St Gelais, Corine ^{[1
]}

Wu, Li ^{[1
,2
]}

机构：

[1] Ohio State Univ, Ctr Retrovirus Res, Dept Vet Biosci, Columbus, OH 43210 USA

[2] Ohio State Univ, Ctr Retrovirus Res, Dept Microbial Infect & Immun, Columbus, OH 43210 USA

来源：

HIV INTERACTIONS WITH DENDRITIC CELLS: INFECTION AND IMMUNITY | 2013年 / 762卷

关键词：

HUMAN-IMMUNODEFICIENCY-VIRUS; ADAPTIVE IMMUNE-RESPONSES; TOLL-LIKE RECEPTORS; CD4(+) T-CELLS; DC-SIGN; TRANS-INFECTION; VIROLOGICAL SYNAPSE; IMMUNOLOGICAL SYNAPSE; PRODUCTIVE INFECTION; TYPE-1; TRANSMISSION;

D O I：

10.1007/978-1-4614-4433-6_4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Dendritic cells (DCs) play a key role in the initial infection and cell-to-cell transmission events that occur upon HIV-1 infection. DCs interact closely with CD4(+) T cells, the main target of HIV-1 replication. HIV-1 challenged DCs and target CD4(+) T cells form a virological synapse that allows highly efficient transmission of HIV-1 to the target CD4(+) T cells, in the absence of productive HIV-1 replication in the DCs. Immature and subsets of mature DCs show distinct patterns of HIV-1 replication and cell-to-cell transmission, depending upon the maturation stimulus that is used. The cellular and viral mechanisms that promote formation of the virological synapse have been the subject of intense study and the most recent progress is discussed here. Characterizing the cellular and viral factors that affect DC-mediated cell-to-cell transmission of HIV-1 to CD4(+) T cells is vitally important to understanding, and potentially blocking, the initial dissemination of HIV-1 in vivo.

引用

页码：109 / 130

页数：22

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