Sphingolipids and the unfolded protein response

被引：22

作者：

Bennett, Melissa K. ^{[1
,2
]}

Wallington-Beddoe, Craig T. ^{[1
,2
,3
,4
,5
]}

Pitson, Stuart M. ^{[1
,2
,3
,6
]}

机构：

[1] Univ South Australia, Ctr Canc Biol, UniSA CRI Bldg,North Tce, Adelaide, SA 5001, Australia

[2] SA Pathol, UniSA CRI Bldg,North Tce, Adelaide, SA 5001, Australia

[3] Univ Adelaide, Adelaide Med Sch, Adelaide, SA 5001, Australia

[4] Flinders Med Ctr, Bedford Pk, SA 5042, Australia

[5] Flinders Univ S Australia, Coll Med & Publ Hlth, Bedford Pk, SA 5042, Australia

[6] Univ Adelaide, Sch Biol Sci, Adelaide, SA 5000, Australia

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2019年 / 10期

基金：

英国医学研究理事会; 澳大利亚国家健康与医学研究理事会;

关键词：

Sphingolipids; Ceramide; Unfolded protein response; Endoplasmic reticulum stress; ENDOPLASMIC-RETICULUM STRESS; SPHINGOSINE KINASE 2; BETA-CELL APOPTOSIS; ER-STRESS; GLUCOSYLCERAMIDE SYNTHASE; DEPENDENT REGULATION; LIPID RAFTS; FATTY-ACIDS; CERAMIDE; ACTIVATION;

D O I：

10.1016/j.bbalip.2019.06.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The unfolded protein response (UPR) is a response by the endoplasmic reticulum to stress, classically caused by any disruption to cell homeostasis that results in an accumulation in unfolded proteins. However, there is an increasing body of research demonstrating that the UPR can also be activated by changes in lipid homeostasis, including changes in sphingolipid metabolism. Sphingolipids are a family of bioactive lipids with important roles in both the formation and integrity of cellular membranes, and regulation of key cellular processes, including cell proliferation and apoptosis. Bi-directional interactions between sphingolipids and the UPR have now been observed in a range of diseases, including cancer, diabetes and liver disease. Determining how these two key cellular components influence each other could play an important role in deciphering the causes of these diseases and potentially reveal new therapeutic approaches.

引用

页码：1483 / 1494

页数：12

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