AXITINIB Targets Gatekeeper-Mutant BCR-ABL1(T315I)-Driven Leukemia in a Distinct And Selective Fashion

被引:0
|
作者
Pemovska, T. [1 ]
Johnson, E. [2 ]
Kontro, M. [3 ,4 ]
Repasky, G. A. [1 ]
Chen, J. [2 ]
Wells, P. [2 ]
Cronin, C. [2 ]
McTigue, M. [2 ]
Kallioniemi, O. [1 ]
Porkka, K. [3 ,4 ]
Murray, B. W. [2 ]
Wennerberg, K. [1 ]
机构
[1] Univ Helsinki, FIMM, Helsinki, Finland
[2] Pfizer Worldwide Res & Dev, Oncol Res Unit, San Diego, CA USA
[3] Univ Helsinki, Cent Hosp, Ctr Comprehens Canc, Helsinki, Finland
[4] Univ Helsinki, Helsinki, Finland
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
51
引用
收藏
页码:S90 / S91
页数:2
相关论文
共 50 条
  • [21] Asciminib, a Specific Allosteric BCR-ABL1 Inhibitor, in Patients with Chronic Myeloid Leukemia Carrying the T315I Mutation in a Phase 1 Trial
    Rea, Delphine
    Lang, Fabian
    Kim, Dong-Wook
    Cortes, Jorge E.
    Hughes, Timothy P.
    Minami, Hironobu
    Breccia, Massimo
    Deangelo, Daniel J.
    Hochhaus, Andreas
    Talpaz, Moshe
    Goh, Yeow Tee
    le Coutre, Philipp
    Deininger, Michael W.
    Etienne, Gabriel
    Sondhi, Manu
    Mishra, Kaushal
    Aimone, Paola
    Ng-Sikorski, Janet
    Mauro, Michael J.
    BLOOD, 2018, 132
  • [22] Combined Effects of a Pan-ABL1 Kinase Inhibitor, Ponatinib and Dasatinib Against T315I Mutant Forms of BCR-ABL1: In Vitro and In Vivo Studies
    Tauchi, Tetsuzo
    Katagiri, Seiichiro
    Okabe, Seiichi
    Ashihara, Eishi
    Kimura, Shinya
    Maekawa, Taira
    Ohyashiki, Kazuma
    BLOOD, 2011, 118 (21) : 1063 - 1064
  • [23] Effects of NT157 on tyrosine kinase signaling pathways in BCR-ABL1 T315I cells
    Silvestrini, Virginia Campos
    Vargas, Alessandra Pinto
    Masson, Ana Paula
    Thome, Carolina Hassibe
    Fonseca, Natasha Peixoto
    Fenerich, Bruna Alves
    Alves Silva, Antonio Bruno
    Traina, Fabiola
    Faca, Vitor Marcel
    BIOPHYSICAL REVIEWS, 2021, 13 (06) : 1438 - 1438
  • [24] MK-0457, an Aurora kinase and BCR–ABL inhibitor, is active in patients with BCR–ABL T315I leukemia
    F J Giles
    R T Swords
    A Nagler
    A Hochhaus
    O G Ottmann
    D A Rizzieri
    M Talpaz
    J Clark
    P Watson
    A Xiao
    B Zhao
    D Bergstrom
    P D Le Coutre
    S J Freedman
    J E Cortes
    Leukemia, 2013, 27 : 113 - 117
  • [25] Discovery of 5-(arenethynyl) monocyclic derivatives as potent inhibitors of native BCR-ABL including the T315I gatekeeper mutant
    Thomas, Mathew
    Huang, Wei-Sheng
    Wen, David
    Zhu, Xiaotian
    Wang, Yihan
    Metcalf, Chester A.
    Liu, Shuangying
    Romero, Jan
    Dong, Zou
    Li, Feng
    Qi, Jiwei
    Xu, Qihong
    Keats, Jeffrey
    Wang, Frank
    Wardwell, Scott
    Ning, Yaoyu
    Snodgrass, Joseph T.
    Broudy, Marc I.
    Russian, Karin
    Iuliucci, John
    Rivera, Victor M.
    Sawyer, Tomi K.
    Dalgarno, David
    Clackson, Tim
    Shakespeare, William C.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2010, 240
  • [26] Derivates of 1,6-dihyadroazaazulenes as inhibitors of tyrosine kinases BCR-ABL1 wild type and mutant T315I: a molecular dynamics approach
    Solis-Hernandez, Manuel de Jesus
    Palomares-Baez, Juan Pedro
    Herrera-Bucio, Rafael
    Chacon-Garcia, Luis
    Navarro-Santos, Pedro
    JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2024, 42 (24): : 13864 - 13875
  • [27] The molecular signature of BCR::ABL P210 and BCR::ABL T315I in a Drosophila melanogaster chronic leukemia model
    Baassiri, Amro
    Ghais, Ali
    Kurdi, Abdallah
    Rahal, Elias
    Nasr, Rihab
    Shirinian, Margret
    ISCIENCE, 2024, 27 (04)
  • [28] Therapeutic options against BCR-ABL1 T315I-positive chronic myelogenous leukemia
    Quintas-Cardama, Alfonso
    Cortes, Jorge
    CLINICAL CANCER RESEARCH, 2008, 14 (14) : 4392 - 4399
  • [29] Discovery of 5-(arenethynyl) hetero-monocyclic derivatives as potent inhibitors of BCR-ABL including the T315I gatekeeper mutant
    Thomas, Mathew
    Huang, Wei-Sheng
    Wen, David
    Zhu, Xiaotian
    Wang, Yihan
    Metcalf, Chester A.
    Liu, Shuangying
    Chen, Ingrid
    Romero, Jan
    Zou, Dong
    Sundaramoorthi, Raji
    Li, Feng
    Qi, Jiwei
    Cai, Lisi
    Zhou, Tianjun
    Commodore, Lois
    Xu, Qihong
    Keats, Jeff
    Wang, Frank
    Wardwell, Scott
    Ning, Yaoyu
    Snodgrass, Joseph T.
    Broudy, Marc I.
    Russian, Karin
    Iuliucci, John
    Rivera, Victor M.
    Sawyer, Tomi K.
    Dalgarno, David C.
    Clackson, Tim
    Shakespeare, William C.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 21 (12) : 3743 - 3748
  • [30] Validation of a Drosophila model of wild-type and T315I mutated BCR-ABL1 in chronic myeloid leukemia: an effective platform for treatment screening
    Al Outa, Amani
    Abubaker, Dana
    Bazarbachi, Ali
    El Sabban, Marwan
    Shirinian, Margret
    Nosr, Rihab
    HAEMATOLOGICA, 2020, 105 (02) : 387 - 397