rhG-CSF mobilisation and collection of peripheral blood progenitor cells in 71 healthy donors

被引：0

作者：

Pönisch, W ^{[1
]}

Leiblein, S ^{[1
]}

Edel, E ^{[1
]}

Kubel, M ^{[1
]}

Riese, F ^{[1
]}

Wolff, D ^{[1
]}

Lange, T ^{[1
]}

Becker, C ^{[1
]}

Liebmann, A ^{[1
]}

Helbig, W ^{[1
]}

Niederwieser, D ^{[1
]}

机构：

[1] Univ Leipzig, Div Haematol Oncol, D-7010 Leipzig, Germany

来源：

HIGH-DOSE THERAPY AND TRANSPLANTATION OF HAEMATOPOIETIC STEM CELLS | 2000年

关键词：

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Despite the extensive use of G-CSF for mobilisation of peripheral blood progenitor cells, the optimal schedule and dose of growth factor has not been established. Our results suggest that administration of G-CSF in normal donors (2 x 5 mg/kg/day) can mobilise sufficient numbers of progenitor cells in the peripheral blood starting between 48 and 72 h after initiation of G-CSF treatment and reaching a maximum level at day 4. A single apheresis with a large volume (4.5-fold of blood volume) at day 4 allowed the collection of the required number of stem cells (> 4 x 10(6) CD34+ cells/kg) fur allogeneic transplantation with lower costs and lower stress for the donor than two aphereses with a normal volume.

引用

页码：94 / 97

页数：4

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