A CONVENIENT PROCEDURE FOR THEREDUCTION OF AMINOACIDS AND AMIDES USING TETRABUTYLAMMONIUM FLUORIDE AND POLYMETHYLHYDROSILOXANE

被引：0

作者：

Drid, Mohammed Elahbib ^{[1
,2
]}

Sekhri, Lakhdar ^{[1
]}

Rahim, Oum Elkheir ^{[2
]}

Syed, Abdelkader Hadj ^{[1
]}

Tabchouche, Ahmed ^{[1
]}

机构：

[1] Univ Kasdi Merbah, Fac Appl Sci, Proc Engn Dept, Lab Dynam Interact & React Syst, Ouargla 30000, Algeria

[2] Univ Kasdi Merbah, Fac Math & Matter Sci, Chem Dept, Electrochem Lab, Ouargla 30000, Algeria

来源：

HETEROCYCLIC LETTERS | 2019年 / 9卷 / 03期

关键词：

Reduction; PMHS; TBAF; alpha-aminoacids; amides; CARBOXYLIC-ACIDS; REDUCTION; ESTERS;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A range of alpha-aminoacids(1a-1h)have been converted efficiently to the corresponding beta-aminoalcohols: 2-amino-3-methylpentan-1-ol (isoleucinol) (2a), 2-amino-4-(methylthio)butan-1-ol (methioninol) (2b), 2-amino-3-methylbutan-1-ol (valinol) (2c), 2-amino-3-(4'-hydroxyphenyl) propan-1-ol (tyrosinol) (2d), 2-amino-3-phenylethan-1-ol (phenylglycinol) (2e), 2-amino-3-phenylpropan-1-ol (phenylalaninol) (2f), 2-aminoethan-1-ol (glycinol) (2g), and 2-aminopropanol-1-ol (alaninol) (2h), with polymethylhydrosiloxane, PMHS, in the presence of catalytic tetrabutylammonium fluoride, TBAF with > 61% yield. Carboxylic acids and their derivatives such as amides(3a and 3b) have also been reducedto the corresponding amines: N-ethylaniline(4a) and N-methylaniline(4b) with polymethylhydrosiloxane, PMHS, in the presence of catalytic tetrabutylammonium fluoride, TBAF with > 74% yield.

引用

页码：309 / 319

页数：11

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