The effects of bacteriophages on the expression of genes involved in antimicrobial immunity

被引：11
|
作者：
Borysowski, Jan [1 ]
Przybylski, Maciej [2 ]
Miedzybrodzki, Ryszard [1 ,3 ]
Owczarek, Barbara [3 ]
Gorski, Andrzej [3 ]
机构：
[1] Med Univ Warsaw, Dept Clin Immunol, Nowogrodzka 59, PL-02006 Warsaw, Poland
[2] Med Univ Warsaw, Dept Med Microbiol, Warsaw, Poland
[3] Polish Acad Sci, Hirszfeld Inst Immunol & Expt Therapy, Bacteriophage Lab, Wroclaw, Poland
来源：
POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ | 2019年 / 73卷
关键词：
phage; gene expression; immunity; IL-2-Toll-like receptor; NATURAL-KILLER-CELLS; TRANSPLANTATION; PHAGES;
D O I：
10.5604/01.3001.0013.4081
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Introduction: Bacteriophages (viruses of bacteria) are used in the treatment of antibiotic-resistant infections. Moreover, they are an important component of the mucosal microbiota. The objective of this study was to investigate the effects of T4 and A5/80 bacteriophages on the expression of genes involved in antimicrobial immunity, including Toll-like receptors. Material/Methods: The expression of genes was determined in the A549 cell line using RT 2 Profiler PCR Array. Results: Purified T4 and A5/80 phage preparations significantly affected the expression of 7 and 10 out of 84 examined genes, respectively. Discussion: Our results are important for phage therapy of bacterial infections and provide novel insights into the role of phages from the mucosal microbiota. They may also lead to novel applications of phages as antiviral and immunomodulatory agents.
引用
收藏
页码：414 / 420
页数：7
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