Expression and significance of RRBP1 in esophageal carcinoma

被引：13
|
作者：
Wang, Liang [1 ]
Wang, Ming [2 ]
Zhang, Mingyun [1 ]
Li, Xingde [1 ]
Zhu, Zhongcheng [1 ]
Wang, Haiyan [2 ]
机构：
[1] Cangzhou Cent Hosp, Dept Endoscop Profess, 16 Xinhua West Rd, Cangzhou 061001, Peoples R China
[2] Cangzhou Cent Hosp, Dept Radiat Therapy, Cangzhou, Peoples R China
来源：
CANCER MANAGEMENT AND RESEARCH | 2018年 / 10卷
关键词：
RRBP1; prognosis; esophageal carcinoma; survival analysis; PREDICTS POOR-PROGNOSIS; RIBOSOME-BINDING PROTEIN-1; SQUAMOUS-CELL CARCINOMA; ENDOPLASMIC-RETICULUM; COLORECTAL-CANCER; TUMOR; OVEREXPRESSION; PROGRESSION; SURVIVAL; RECEPTOR;
D O I：
10.2147/CMAR.S158013
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Objective: This study was to investigate the expression and clinical significance of RRBP1 in esophageal carcinoma. Materials and methods: RRBP1 expression was detected in 120 esophageal carcinoma and matched adjacent normal tissues, and the relationship of RRBP1 with clinicopathological characteristics and prognosis was analyzed. Results: RRBP1 was highly expressed in esophageal carcinoma tissues compared with matched adjacent normal tissues (P< 0.05). Moreover, RRBP1 expression was associated with T stage, lymph node metastasis, and TNM stage in esophageal carcinoma (P< 0.05). Survival analysis revealed that RRBP1, T stage, lymph node metastasis, and TNM stage were significantly associated with patients' prognosis. Conclusion: RRBP1 is highly expressed in esophageal carcinoma and can serve as a potential biomarker to predict patients' prognosis.
引用
收藏
页码：1243 / 1249
页数：7
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