Within the next 10 years it is most unlikely for a major discovery to significantly transform the necessity of calling for red blood cells, platelets and plasma as a substitute treatment for the human population. Blood products are 'doomed' to a human origin, ever, the same way as calling for human blood donation is forever to stay. Consequently, practice development and improvement has to be constantly enhanced for an ever increasing quality and efficiency treatment to be provided to the patient. This article describes such critical items subject to progress, such as donation, self-sufficiency, medical practice, quality assurance, risk management, regulations, socio-economic aspects, biotechnologies, research and training.