The role of systemic and targeted therapies in brain metastases

被引：5

作者：

Franceschi, Enrico ^{[1
]}

Bartolotti, Marco ^{[1
]}

Poggi, Rosalba ^{[1
]}

Di Battista, Monica ^{[1
]}

Palleschi, Dario ^{[1
]}

Brandes, Alba A. ^{[1
]}

机构：

[1] Azienda USL Bologna, Bellaria Maggiore Hosp, Dept Med Oncol, I-40139 Bologna, Italy

来源：

EXPERT REVIEW OF ANTICANCER THERAPY | 2014年 / 14卷 / 01期

关键词：

BRAF V600E melanoma; brain metastases; EGFR mutations; HER2 breast cancer; target therapy; CELL LUNG-CANCER; LAPATINIB PLUS CAPECITABINE; PHASE-II TRIAL; TYROSINE KINASE INHIBITORS; EARLY BREAST-CANCER; RADIATION-THERAPY; OPEN-LABEL; INTRACRANIAL METASTASES; ADJUVANT TRASTUZUMAB; CEREBRAL METASTASES;

D O I：

10.1586/14737140.2014.856760

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

For many years, brain metastases (BMs) have been considered as the final stage of a disease course and engendered skepticism about the efficacy of treatments. Local treatments, mainly, whole-brain radiotherapy have been the standard of care, whereas chemotherapy has been considered of limited efficacy due to the potential role of blood-brain barrier.

引用

页码：93 / 103

页数：11

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