Role of toll-like receptors in lung cancer

被引：10
|
作者：
Yang, Liu-Shan [1 ]
Wu, Wen-Sen [1 ]
Zhang, Fu [1 ]
Jiang, Yi [1 ]
Fan, Yue [1 ]
Fang, Heng-Xiao [1 ]
Long, Ju [1 ]
机构：
[1] Guangxi Univ Tradit Chinese Med, Affiliated Ruikang Hosp, Dept Cardiothorac Surg, Nanning 530011, Peoples R China
来源：
JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION | 2014年 / 34卷 / 05期
关键词：
Toll-like receptors; signaling pathways; lung cancer; NONSMALL CELL LUNG; TARGETING TOLL-LIKE-RECEPTOR-9; SIGNALING PATHWAYS; EXPRESSION; TLR9; PROMOTES; METASTASIS; ESCAPE; GROWTH;
D O I：
10.3109/10799893.2014.903418
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Lung cancer is a leading cause of death world-wide and the long-term survival rate for patients with lung cancer is one of the lowest for any cancer. Toll-like receptors (TLRs), evolutionarily conserved innate, are expressed in a wide variety of tissues and cell types, and they play key role in the innate immune system. TLRs have been found to be expressed by some kinds of tumor cells. However, what is the biological function of TLRs on tumor cells and whether human lung cancer cells can express TLRs remain to be fully understood. This review was performed to sum up the role of TLRs in lung cancer.
引用
收藏
页码：342 / 344
页数：3
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