Clinical characteristics and outcome of respiratory syncytial virus infection among adults hospitalized with influenza-like illness in France

被引：76

作者：

Loubet, P. ^{[1
,2
]}

Lenzi, N. ^{[3
]}

Valette, M. ^{[4
]}

Foulongne, V. ^{[5
]}

Krivine, A. ^{[6
]}

Houhou, N. ^{[7
]}

Lagathu, G. ^{[8
]}

Rogez, S. ^{[9
]}

Alain, S. ^{[10
]}

Duval, X. ^{[1
,11
]}

Galtier, F. ^{[3
,12
]}

Postil, D. ^{[13
]}

Tattevin, P. ^{[14
]}

Vanhems, P. ^{[15
,16
]}

Carrat, F. ^{[17
,18
]}

Lina, B. ^{[4
,19
]}

Launay, O. ^{[3
,20
,21
,22
]}

机构：

[1] Univ Paris Diderot, Sorbonne Paris Cite, INSERM, IAME,UMR 1137, Paris, France

[2] Hop Bichat Claude Bernard, AP HP, Serv Malad Infectieuses & Trop, Paris, France

[3] INSERM, F CRIN, Innovat Clin Res Network Vaccinol I REIVAC, Paris, France

[4] Hosp Civils Lyon, GHN, Inst Agents Infectieux, CNR Virus Influenza, Lyon, France

[5] CHU Montpellier, Hop St Eloi, Inserm U 1058, Laboratoire Virol, Montpellier, France

[6] Hop Cochin Broca Hotel Dieu, AP HP, Lab Virol, Paris, France

[7] Hop Bichat Claude Bernard, AP HP, Lab Virol, Paris, France

[8] CHRU Pontchaillou, Lab Virol, Rennes, France

[9] CHU Dupuytren, Serv Bacteriol Virol Hyg, Limoges, France

[10] CHU Dupuytren, Lab Virol, Limoges, France

[11] Hop Bichat Claude Bernard, AP HP, Inserm CIC 1425, Paris, France

[12] CHU Montpellier, Hop Saint Eloi, Inserm CIC 1411, Montpellier, France

[13] CHU Dupuytren, CIC 1435, Limoges, France

[14] CHRU Pontchaillou, Malad Infect & Reanimat Med, CIC INSERM 1414, Rennes, France

[15] Grp Hosp Edouard Herriot, Serv Hyg Epidemiol & Prevent, Lyon, France

[16] CIRI, Inserm U1111, CNRS UMR5308, ENS Lyon,Emerging Pathogens Lab Fdn Merieux,UCBL1, Lyon, France

[17] Sorbonne Univ, UPMC Univ Paris 06, INSERM, Inst Pierre Louis Epidemiol & Sante Publ IPLESP U, Paris, France

[18] Hop Saint Antoine, AP HP, Publ Hlth Dept, Paris, France

[19] Univ Lyon, Hosp Civils Lyon, CIRI,CNRS,UMR5308,Ecole Normale Super Lyon, Virpath,Inserm U1111,Univ Claude Bernard Lyon 1, Lyon, France

[20] INSERM, CIC 1417, Paris, France

[21] Univ Paris 05, Sorbonne Paris Cite, Paris, France

[22] Cochin Broca Hotel Dieu Hosp, AP HP, Dept Infect Dis, CIC Cochin Pasteur, Paris, France

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2017年 / 23卷 / 04期

关键词：

Respiratory syncytial virus; Pneumonia; Adults; Influenza-like illness; Influenza; Elderly; OLDER-ADULTS; RISK-FACTORS;

D O I：

10.1016/j.cmi.2016.11.014

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Objectives: The aim of this study was to analyse characteristics and outcome of respiratory syncytial virus (RSV) infection in adults hospitalized with influenza-like illness (ILI). Methods: Patients hospitalized with ILI were included in this prospective, multicentre study carried out in six French hospitals during three consecutive influenza seasons (2012-2015). RSV and other respiratory viruses were detected by multiplex PCR in nasopharyngeal swabs. Risk factors for RSV infection were identified by backward stepwise logistic regression analysis. Results: A total of 1452 patients hospitalized with ILI were included, of whom 59% (861/1452) were >65 years and 83% (1211/1452) had underlying chronic illnesses. RSV was detected in 4% (59/1452), and influenza virus in 39% (566/1452). Risk factors for RSV infection were cancer (adjusted OR 2.1, 95% CI 1.1 -4.1, p 0.04), and immunosuppressive treatment (adjusted OR 2.0, 95% CI 1.1-3.8, p 0.03). Patients with RSV had a median length of stay of 9 days (6-25), and 57% of them (30/53) had complications, including pneumonia (23/53, 44%) and respiratory failure (15/53, 28%). Fifteen per cent (8/53) were admitted to an intensive care unit, and the in-hospital mortality rate was 8% (4/53). Pneumonia was more likely to occur in patients with RSV than in patients with RSV-negative ILI (44% (23/53) versus 26% (362/1393), p 0.006) or with influenza virus infection (44% versus 28% (157/560), p 0.02). Conclusion: RSV is an infrequent cause of ILI during periods of influenza virus circulation but can cause severe complications in hospitalized adults. Risk factors for RSV detection in adults hospitalized with ILI include cancer and immunosuppressive treatment. Specific immunization and antiviral therapy might benefit patients at risk. (C) 2016 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

引用

页码：253 / 259

页数：7

共 50 条

[41] Clinical characteristics of patients hospitalized for acute respiratory infection associated with Influenza Virus
Rojas Rios, A. M.
Gerbeno, F. A.
Penco, S.
Moreno, S.
Martin, G.
[J]. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2018, 73 : 268 - 269
[42] Multicenter evaluation of molecular point-of-care testing and digital immunoassays for influenza virus A/B and respiratory syncytial virus in patients with influenza-like illness
Kaku, Norihito
Kodama, Hina
Akamatsu, Norihiko
Ota, Kenji
Kosai, Kosuke
Morinaga, Yoshitomo
Narita, Yusuke
Matsumoto, Yasushi
Matsushita, Tetsuro
Mizuta, Yohei
Izumikawa, Koichi
Mukae, Hiroshi
Yanagihara, Katsunori
[J]. JOURNAL OF INFECTION AND CHEMOTHERAPY, 2021, 27 (06) : 820 - 825
[43] Status of acute upper respiratory infection,influenza-like illness,and influenza vaccination coverage among community residents in Jinan
刘营
[J]. China Medical Abstracts (Internal Medicine), 2016, 33 (01) : 16 - 17
[44] Severity of Respiratory Syncytial Virus vs COVID-19 and Influenza Among Hospitalized US Adults
Surie, Diya
Yuengling, Katharine A.
DeCuir, Jennifer
Zhu, Yuwei
Lauring, Adam S.
Gaglani, Manjusha
Ghamande, Shekhar
Peltan, Ithan D.
Brown, Samuel M.
Ginde, Adit A.
Martinez, Amanda
Mohr, Nicholas M.
Gibbs, Kevin W.
Hager, David N.
Ali, Harith
Prekker, Matthew E.
Gong, Michelle N.
Mohamed, Amira
Johnson, Nicholas J.
Srinivasan, Vasisht
Steingrub, Jay S.
Leis, Aleda M.
Khan, Akram
Hough, Catherine L.
Bender, William S.
Duggal, Abhijit
Bendall, Emily E.
Wilson, Jennifer G.
Qadir, Nida
Chang, Steven Y.
Mallow, Christopher
Kwon, Jennie H.
Exline, Matthew C.
Shapiro, Nathan I.
Columbus, Cristie
Vaughn, Ivana A.
Ramesh, Mayur
Mosier, Jarrod M.
Safdar, Basmah
Casey, Jonathan D.
Talbot, H. Keipp
Rice, Todd W.
Halasa, Natasha
Chappell, James D.
Grijalva, Carlos G.
Baughman, Adrienne
Womack, Kelsey N.
Swan, Sydney A.
Johnson, Cassandra A.
Lwin, Cara T.
[J]. JAMA NETWORK OPEN, 2024, 7 (04) : E244954
[45] Comparison of clinical characteristics of influenza and respiratory syncytial virus infection in hospitalised children and adolescents
Meury, S
Zeller, S
Heininger, U
[J]. EUROPEAN JOURNAL OF PEDIATRICS, 2004, 163 (07) : 359 - 363
[46] Comparison of clinical characteristics of influenza and respiratory syncytial virus infection in hospitalised children and adolescents
Susanne Meury
Sven Zeller
Ulrich Heininger
[J]. European Journal of Pediatrics, 2004, 163 : 359 - 363
[47] Characteristics of Respiratory Syncytial Virus versus Influenza Infection in Hospitalized Patients of Peru: A Retrospective Observational Study
Carlos Ramirez-Soto, Max
Ortega-Caceres, Gutia
Garay-Uribe, Jose
[J]. TROPICAL MEDICINE AND INFECTIOUS DISEASE, 2022, 7 (10)
[48] Burden of respiratory syncytial virus, human metapneumovirus and influenza virus infections in Japanese adults in the Hospitalized Acute Respiratory Tract Infection study
Shinkai, Masaharu
Ota, Shinichiro
Ishikawa, Nobuhisa
Tanimoto, Takuya
Suzuki, Hiroki
Abe, Shuichi
Vandendijck, Yannick
Nakayama, Yoshikazu
Murata, Yoko
[J]. RESPIRATORY INVESTIGATION, 2024, 62 (04) : 717 - 725
[49] Respiratory syncytial virus is an important cause of community-acquired lower respiratory infection among hospitalized adults
Dowell, SF
Anderson, LJ
Gary, HE
Erdman, DD
Plouffe, JF
File, TM
Marston, BJ
Breiman, RF
[J]. JOURNAL OF INFECTIOUS DISEASES, 1996, 174 (03): : 456 - 462
[50] Cost of illness due to respiratory syncytial virus acute lower respiratory tract infection among infants hospitalized in Argentina
Julia Dvorkin
Emiliano Sosa
Elizabeth Vodicka
Ranju Baral
Andrea Sancilio
Karina Dueñas
Andrea Rodriguez
Carlos Rojas-Roque
Patricia B. Carruitero
Fernando P. Polack
Clint Pecenka
Romina Libster
Mauricio T. Caballero
[J]. BMC Public Health, 24

← 1 2 3 4 5 →