Hetarylfuroxans: cytotoxic effect and induction of apoptosis in chronic myeloid leukemia K562 cells

被引：8

作者：

Pukhov, S. A. ^{[1
]}

Anikina, L. A. ^{[1
]}

Larin, A. A. ^{[2
]}

Fershtat, L. L. ^{[2
]}

Kulikov, A. S. ^{[2
]}

Makhova, N. N. ^{[2
]}

机构：

[1] Russian Acad Sci, Inst Physiol Act Cpds, 1 Severnyi Proezd, Chernogolovka 142432, Moscow Region, Russia

[2] Russian Acad Sci, ND Zelinsky Inst Organ Chem, 47 Leninsky Prosp, Moscow 119991, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2019年 / 68卷 / 01期

基金：

俄罗斯基础研究基金会;

关键词：

cytotoxicity; chronic myeloid leukemia K562; hetarylfuroxans; apoptosis; caspase-3; caspase-7; ANTIAGGREGANT ACTIVITY; TYROSINE KINASE; INHIBITORS; FUROXANS; SYSTEMS; EVENTS; DESIGN;

D O I：

10.1007/s11172-019-2431-5

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Hetarylfuroxans (4-(2-methylpyridin-5-yloxy)-3-phenylfuroxan (1), bis(1,2,4-oxadiazol-3-yl)furoxan (2), and 4-amino-3-(indenotriazin-3-yl)furoxan (3)) exhibit in vitro cytotoxic activity against chronic myeloid leukemia K562 cells. All studied furoxans induce apoptosis in K562 cells. The experiments with activation of caspases-3 and -7 showed that furoxan 3 possessed the highest apoptosis-inducing capacity. The studied hetarylfuroxans were found to be the promising drug candidates for the treatment of chronic myeloid leukemia K562.

引用

页码：158 / 162

页数：5

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