Hetarylfuroxans: cytotoxic effect and induction of apoptosis in chronic myeloid leukemia K562 cells

被引：8
|
作者：
Pukhov, S. A. [1 ]
Anikina, L. A. [1 ]
Larin, A. A. [2 ]
Fershtat, L. L. [2 ]
Kulikov, A. S. [2 ]
Makhova, N. N. [2 ]
机构：
[1] Russian Acad Sci, Inst Physiol Act Cpds, 1 Severnyi Proezd, Chernogolovka 142432, Moscow Region, Russia
[2] Russian Acad Sci, ND Zelinsky Inst Organ Chem, 47 Leninsky Prosp, Moscow 119991, Russia
来源：
RUSSIAN CHEMICAL BULLETIN | 2019年 / 68卷 / 01期
基金：
俄罗斯基础研究基金会;
关键词：
cytotoxicity; chronic myeloid leukemia K562; hetarylfuroxans; apoptosis; caspase-3; caspase-7; ANTIAGGREGANT ACTIVITY; TYROSINE KINASE; INHIBITORS; FUROXANS; SYSTEMS; EVENTS; DESIGN;
D O I：
10.1007/s11172-019-2431-5
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Hetarylfuroxans (4-(2-methylpyridin-5-yloxy)-3-phenylfuroxan (1), bis(1,2,4-oxadiazol-3-yl)furoxan (2), and 4-amino-3-(indenotriazin-3-yl)furoxan (3)) exhibit in vitro cytotoxic activity against chronic myeloid leukemia K562 cells. All studied furoxans induce apoptosis in K562 cells. The experiments with activation of caspases-3 and -7 showed that furoxan 3 possessed the highest apoptosis-inducing capacity. The studied hetarylfuroxans were found to be the promising drug candidates for the treatment of chronic myeloid leukemia K562.
引用
收藏
页码：158 / 162
页数：5
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