Therapeutic targeting of gastrointestinal cancer stem cells

被引：15
|
作者：
Stem, Jonathan [1 ]
Flickinger, John C., Jr. [2 ]
Merlino, Dante [2 ]
Caparosa, Ellen M. [1 ,2 ]
Snook, Adame [2 ]
Waldman, Scott A. [2 ]
机构：
[1] Dept Surg, 1020 Locust St,JAH368, Philadelphia, PA 19107 USA
[2] 1020 Locust St,JAH368, Philadelphia, PA 19107 USA
来源：
REGENERATIVE MEDICINE | 2019年 / 14卷 / 04期
关键词：
cancer stem cells; chemoresistance; gastrointestinal cancer; immunotherapy; radioresistance; targeted therapies; ACUTE MYELOID-LEUKEMIA; TRANS-RETINOIC ACID; COLON-CANCER; INITIATING CELLS; TUMOR-GROWTH; PHASE-II; T-CELLS; GAMMA; IDENTIFICATION; TELOMERASE;
D O I：
10.2217/rme-2018-0146
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Gastrointestinal cancers remain a tremendous burden on society. Despite advances in therapy options, including chemotherapy and radiation, cancer mortality from recurrences and metastases occur frequently. Cancer stem cells (CSCs) drive disease recurrence and metastasis, as these cells are uniquely equipped to self-renew and evade therapy. Therefore, cancer eradication requires treatment strategies that target CSCs in addition to differentiated cancer cells. This review highlights current literature on therapies targeting CSCs in gastrointestinal cancer.
引用
收藏
页码：331 / 343
页数：13
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