Present and future of metastatic colorectal cancer treatment: A review of new candidate targets

被引：89

作者：

Martini, Giulia ^{[1
]}

Troiani, Teresa ^{[1
]}

Cardone, Claudia ^{[1
]}

Vitiello, Pietropaolo ^{[1
]}

Sforza, Vincenzo ^{[1
]}

Ciardiello, Davide ^{[1
]}

Napolitano, Stefania ^{[1
]}

Della Corte, Carminia Maria ^{[1
]}

Morgillo, Floriana ^{[1
]}

Raucci, Antonio ^{[2
]}

Cuomo, Antonio ^{[3
]}

Selvaggi, Francesco ^{[4
]}

Ciardiello, Fortunato ^{[1
]}

Martinelli, Erika ^{[1
]}

机构：

[1] Univ Campania Luigi Vanvitelli, Inst Med Oncol, Dept Internal & Expt Med F Magrassi & A Lanzara, Via Pansini 5, I-80131 Naples, Italy

[2] Univ Campania Luigi Vanvitelli, Inst Radiol, Dept Internal & Expt Med Magrassi Lanzara, I-80138 Naples, Italy

[3] Osped Umberto I, Gastroenterol Unit, I-84104 Nocera Inferiore, Italy

[4] Univ Campania Luigi Vanvitelli, Unit Colorectal Surg, Dept Med Surg Neurol Metab & Ageing Sci, I-80138 Naples, Italy

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2017年 / 23卷 / 26期

关键词：

Novel biomarkers; Monoclonal antibodies; Resistance; Mutation; RAS; Target therapy; Metastatic colorectal cancer; WILD-TYPE KRAS; CETUXIMAB PLUS IRINOTECAN; III COLON-CANCER; GROWTH-FACTOR; 1ST-LINE TREATMENT; RAS MUTATIONS; PHASE-II; PTEN EXPRESSION; MISMATCH-REPAIR; OPEN-LABEL;

D O I：

10.3748/wjg.v23.i26.4675

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

In the last two decades, great efforts have been made in the treatment of metastatic colorectal cancer (mCRC) due to the approval of new target agents for cytotoxic drugs. Unfortunately, a large percentage of patients present with metastasis at the time of diagnosis or relapse after a few months. The complex molecular heterogeneity of this disease is not completely understood; to date, there is a lack of predictive biomarkers that can be used to select subsets of patients who may respond to target drugs. Only the RAS-mutation status is used to predict resistance to anti-epidermal growth factor receptor agents in patients with mCRC. In this review, we describe approved targeted therapies for the management of metastatic mCRC and discuss new candidate targets on the horizon.

引用

页码：4675 / 4688

页数：14

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