The effects of resveratrol administration on lipid oxidation in experimental renal ischemia-reperfusion injury in rats

被引：16
|
作者：
Baltaci, A. K. [1 ]
Gokbudak, H. [1 ]
Baltaci, S. B. [1 ]
Mogulkoc, R. [1 ]
Avunduk, M. C. [2 ]
机构：
[1] Selcuk Univ, Fac Med, Dept Physiol, TR-42031 Konya, Turkey
[2] Necmettin Erbakan Univ, Meram Fac Med, Dept Pathol, Konya, Turkey
来源：
BIOTECHNIC & HISTOCHEMISTRY | 2019年 / 94卷 / 08期
关键词：
Histopathology; lipid oxidation; rat; renal ischemia; reperfusion; resveratrol; STRESS;
D O I：
10.1080/10520295.2019.1612091
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
We investigated how resveratrol affects lipid oxidation during experimental renal ischemia-reperfusion injury in rats. We used 48 adult male rats assigned to five groups: group 1, control; group 2, renal ischemia; group 3, renal ischemia + reperfusion; group 4, resveratrol + renal ischemia; group 5, resveratrol + renal ischemia + reperfusion. Plasma and renal tissue malondialdehyde (MDA), and erythrocyte and renal tissue glutathione (GSH) levels were measured and histologic changes in the renal tissue were examined. Ischemia-reperfusion affected the MDA-GSH balance adversely and caused histopathological changes in the renal tissue of the ischemia and ischemia + reperfusion groups. Resveratrol treatment normalized MDA and GSH levels as well as the histopathology that occurred in the renal tissue of the ischemia and ischemia + reperfusion groups.
引用
收藏
页码：592 / 599
页数：8
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