Sesquiterpene dimers from the roots of Chloranthus holostegius with moderate anti-inflammatory activity

被引：23

作者：

Shen, Chuan-Pu ^{[1
]}

Luo, Jian-Guang ^{[1
]}

Yang, Ming-Hua ^{[1
]}

Kong, Ling-Yi ^{[1
]}

机构：

[1] China Pharmaceut Univ, Dept Nat Med Chem, State Key Lab Nat Med, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, Peoples R China

来源：

PHYTOCHEMISTRY | 2017年 / 137卷

关键词：

Chlorathus holostegius; Chloranthaceae; Lindenane sesquiterpene dimers; Anti-inflammatory; C-F; BLOCKERS; POTENT; SEEDS;

D O I：

10.1016/j.phytochem.2017.02.016

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Eight lindenane dimers, chololactones A-H, along with two known compounds, were isolated from the roots of Chloranthus holostegius. Their structures were elucidated using 1D/2D NMR and HRESIMS, and their absolute configurations were determined using the ECD exciton chirality method. All isolates were tested for inhibitory effects on the NO production of the liposaccharide (LPS)-induced RAW 264.7 macrophages, and showed moderate activity with IC50 values at 3.5-35.4 mu M. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：117 / 122

页数：6

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