Clinical course of classic Kaposi's sarcoma in HIV-negative patients treated with the HIV protease inhibitor indinavir

被引：26

作者：

Monini, Paolo ^{[1
]}

Sgadari, Cecilia ^{[1
]}

Grosso, Maria Gabriella ^{[1
]}

Bellino, Stefania ^{[1
]}

Di Biagio, Antonio ^{[2
]}

Toschi, Elena ^{[1
]}

Bacigalupo, Ilaria ^{[1
]}

Sabbatucci, Michela ^{[1
,3
]}

Cencioni, Giulia ^{[1
]}

Salvi, Emanuela ^{[1
]}

Leone, Patrizia ^{[1
]}

Ensoli, Barbara ^{[1
]}

机构：

[1] Ist Super Sanita, Natl AIDS Ctr, I-00161 Rome, Italy

[2] Univ Genoa, Infect Dis Clin, S Martino Hosp, Genoa, Italy

[3] Ist Super Sanita, Dept Cell Biol & Neurosci, I-00161 Rome, Italy

来源：

AIDS | 2009年 / 23卷 / 04期

关键词：

FIBROBLAST-GROWTH-FACTOR; INFLAMMATORY CYTOKINES; ENDOTHELIAL-CELLS; NUDE-MICE; LESION FORMATION; SPINDLE CELLS; TAT PROTEIN; ANGIOGENESIS; ANTIBODIES; INDUCTION;

D O I：

10.1097/QAD.0b013e3283262a8d

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

HIV protease inhibitors have been shown to exert antiangiogenic and antitumor actions independently from their antiretroviral effect. Based on these studies, HIV-seronegative patients with classic Kaposi's sarcoma were treated with indinavir and followed for clinical evolution, drug pharmacokinetics and Kaposi's sarcoma biomarkers. A favorable clinical course was associated with high drug plasma levels, reduced production of basic fibroblast growth factor, lower numbers of circulating endothelial cells, and a decrease in antibody titers against human herpesvirus 8.

引用

页码：534 / 538

页数：5

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