RhIII-catalyzed dual directing group assisted sterically hindered C-H bond activation: a unique route to meta and ortho substituted benzofurans

被引：36

作者：

Yeh, Chien-Hung ^{[1
]}

Chen, Wei-Chen ^{[1
]}

Gandeepan, Parthasarathy ^{[1
]}

Hong, Ya-Chun ^{[1
]}

Shih, Cheng-Hung ^{[1
]}

Cheng, Chien-Hong ^{[1
]}

机构：

[1] Natl Tsing Hua Univ, Dept Chem, Hsinchu 30013, Taiwan

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2014年 / 12卷 / 45期

关键词：

INTERNAL ALKYNES; ISOQUINOLINIUM SALTS; EFFICIENT SYNTHESIS; ARYL HALIDES; ANNULATION; PHENOLS; DERIVATIVES; CYCLIZATION; ARENES; INDOLES;

D O I：

10.1039/c4ob01876a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new strategy for the synthesis of highly substituted benzofurans from meta-substituted hydroxybenzenes and alkynes via a rhodium(III)-catalyzed activation of a sterically hindered C-H bond is demonstrated. A possible mechanism involving dual directing group assisted ortho C-H bond activation is proposed.

引用

页码：9105 / 9108

页数：4

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