Depressive Symptoms, Antidepressant Use, and Hypertension in Young Adulthood

被引:14
|
作者
Crookes, Danielle M. [1 ]
Demmer, Ryan T. [1 ,4 ]
Keyes, Katherine M. [1 ]
Koenen, Karestan C. [2 ]
Suglia, Shakira F. [1 ,3 ]
机构
[1] Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, 722 W 168th St,7th Floor, New York, NY 10032 USA
[2] Harvard Univ, Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA
[3] Emory Univ, Dept Epidemiol, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA
[4] Univ Minnesota, Div Epidemiol & Community Hlth, Sch Publ Hlth, Minneapolis, MN 55455 USA
基金
美国国家卫生研究院;
关键词
Adolescents; Antidepressants; Depressive symptoms; Hypertension; Young adults; BLOOD-PRESSURE; CARDIOVASCULAR-DISEASE; SHORT-FORM; RISK; ADOLESCENCE; ATHEROSCLEROSIS; TRAJECTORIES; ASSOCIATIONS; METAANALYSIS; VENLAFAXINE;
D O I
10.1097/EDE.0000000000000840
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Background: Among adults, depressive symptoms are associated with higher rates of cardiovascular disease; however, the evidence is mixed regarding the association between depressive symptoms and hypertension, especially among young adults. The deleterious effects of some antidepressant medications on blood pressure may contribute to mixed findings. Methods: Adolescents enrolled in Add Health (N = 11,183) (19942008) completed an abbreviated Center for Epidemiologic Studies Depression Scale at three waves (mean ages, 16, 22, and 29). Antidepressant use was measured at age 22 and at age 29. Hypertension at age 29 was defined as measured systolic blood pressure of 140 mm Hg or greater, diastolic blood pressure of 90 mm Hg or greater, or staff-inventoried anti-hypertensive medication use. Results: The prevalence of hypertension at age 29 was 20%. High depressive symptoms in adolescence or young adulthood were not associated with hypertension in young adulthood. Antidepressant use at age 29 was associated with increased prevalence of hypertension (prevalence ratio [PR], 1.4; 95% CI, 1.2, 1.7) and an interaction with sex was observed (PRMen, 1.6; 95% CI, 1.2, 2.0; PRWomen, 1.2; 95% CI, 0.89, 1.6; p(interaction) = 0.0227). Selective serotonin reuptake inhibitor and non-selective serotonin reuptake inhibitor antidepressant use were associated with hypertension (PRSSRI, 1.3; 95% CI, 1.0, 1.6; PRnon-SSRI, 1.6; 95% CI, 1.2, 2.1). Conclusions: In this sample, antidepressant use, but not depressive symptoms, was associated with hypertension in young adulthood. Further research is recommended to examine joint and independent relationships between depression and antidepressant use and hypertension among young adults. See video abstract at, http://links.lww.com/EDE/B355.
引用
收藏
页码:547 / 555
页数:9
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