Impact of the Platelet-to-Lymphocyte Ratio as a Biomarker for Esophageal Squamous Cell Carcinoma

被引：8
|
作者：
Kato, Takashi [1 ]
Oshikiri, Taro [1 ]
Goto, Hironobu [1 ]
Sawada, Ryuichiro [1 ]
Harada, Hitoshi [1 ]
Urakawa, Naoki [1 ]
Hasegawa, Hiroshi [1 ]
Kanaji, Shingo [1 ]
Yamashita, Kimihiro [1 ]
Matsuda, Takeru [2 ]
Kakeji, Yoshihiro [1 ]
机构：
[1] Kobe Univ, Grad Sch Med, Dept Surg, Div Gastrointestinal Surg, Kobe, Hyogo, Japan
[2] Kobe Univ, Grad Sch Med, Dept Surg, Div Minimally Invas Surg, Kobe, Hyogo, Japan
来源：
ANTICANCER RESEARCH | 2022年 / 42卷 / 05期
关键词：
Biomarker; esophageal squamous cell carcinoma; platelet-to-lymphocyte ratio; RECURRENT LARYNGEAL NERVE; CHARACTERISTIC ROC CURVE; LAPAROSCOPIC SURGERY; CANCER; LYMPHADENECTOMY; INFLAMMATION; LEUKOCYTE; SURVIVAL; OUTCOMES;
D O I：
10.21873/anticanres.15757
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background/Aim: Esophageal squamous cell carcinoma (ESCC) is a deadly malignant disease. This study examined whether the platelet-to-lymphocyte ratio (PLR) can be used as a biomarker to evaluate prognosis in patients with advanced ESCC following neoadjuvant chemotherapy (NAC) and undergoing minimally invasive esophagectomy (MIE). Patients and Methods: We examined 174 patients between January 2010 and December 2015 at the Kobe University. Of these, 121 were treated with NAC. The PLR cutoff was determined through receiver-operating characteristic curve analysis. Univariate and multivariate analyses were conducted to identify prognostic factors for overall survival (OS). Results: The PLR cutoff for OS in 121 patients was 169.6. Patients with PLR 169.6 (61.1%, p=0.001). Multivariate analysis revealed that a PLR of 169.6 was an independent factor for poor prognosis. Conclusion: PLR is an independent prognostic factor for patients with ESCC after NAC and MIE.
引用
收藏
页码：2775 / 2782
页数：8
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