An LC-MS/MS method for quantification of demethylzeylasteral, a novel immunosuppressive agent in rat plasma and the application to a pharmacokinetic study

被引：2
|
作者：
Yang, Luoluo [1 ]
Xia, Yan [1 ]
An, Lianhua [2 ]
Zhou, Dan [3 ]
机构：
[1] Jilin Univ, Dept Gastroenterol, Hosp 1, Changchun, Jilin, Peoples R China
[2] Jilin Univ, Dept Sci & Educ, Hosp 1, Changchun, Jilin, Peoples R China
[3] Jilin Univ, Dept Pediat, Hosp 2, Changchun, Jilin, Peoples R China
来源：
BIOMEDICAL CHROMATOGRAPHY | 2018年 / 32卷 / 08期
关键词：
demethylzeylasteral; LC-MS; MS; pharmacokinetic study; rat plasma; KIDNEY-TRANSPLANTATION MODEL; TRIPTERYGIUM-WILFORDII; CA2+ CHANNELS; INHIBITION;
D O I：
10.1002/bmc.4247
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
In this study, a sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the quantification of demethylzeylasteral in rat plasma. Electrospray ionization was operated in the negative ion mode while demethylzeylasteral and oleanolic acid (internal standard) were measured by selected reaction monitoring (demethylzeylasteral: m/z 479.2436.0; oleanolic acid: m/z 454.9407.2). This LC-MS/MS method had good selectivity, sensitivity, accuracy and precision. The pharmacokinetic profiles of demethylzeylasteral were subsequently examined in Wistar rats after oral or intravenous administration.
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页数：6
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