Significantly association of diabetes mellitus with CTLA-4 gene polymorphisms based on a meta-analysis of epidemiological evidence in Asians and non-Asians

被引：2
|
作者：
Liu, J. [1 ,2 ]
Zhang, H. X. [3 ]
Feng, G. Y. [2 ]
He, L. [2 ]
机构：
[1] Shanghai Jiao Tong Univ, Shanghai Key Lab Prevent & Treatment Bone & Joint, Shanghai Inst Orthopaed & Traumatol, Dept Orthopaed,Ruijin Hosp,Sch Med, Shanghai 200030, Peoples R China
[2] Shanghai Jiao Tong Univ, BioX Inst, Key Lab Genet Dev & Neuropsychiat Disorders, Minist Educ, Shanghai 200030, Peoples R China
[3] Shanghai Jiao Tong Univ, Res Ctr Expt Med, State Key Lab Med Genom, Rui Jin Hosp,Sch Med, Shanghai 200030, Peoples R China
来源：
GENETICS AND MOLECULAR RESEARCH | 2013年 / 12卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Diabetes; CTLA-4; gene; Meta-analysis; SNPs; AUTOIMMUNE THYROID-DISEASE; SINGLE NUCLEOTIDE POLYMORPHISMS; A-G POLYMORPHISM; A/G POLYMORPHISM; CONFERS SUSCEPTIBILITY; CHROMOSOME; 2Q33; GRAVES-DISEASE; EARLY-ONSET; TYPE-1; IDDM;
D O I：
10.4238/2013.September.23.11
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We evaluated association of polymorphisms in the CTLA-4 gene with the risk of type 1 diabetes mellitus. Comprehensive meta-analysis was applied to case-control studies of the association between CTLA-4 and type 1 diabetes mellitus to assess the joint evidence for the association, the influence of individual studies, and evidence for publication bias. We searched PubMed, Medline, Embase, Cochrane Library, and reference lists of relevant studies to February 2012, and made email contact with authors. For the case-control studies, we found 1) support for an association between CTLA-4 and type 1 diabetes mellitus, 2) no evidence that this association was accounted for by any one study, and 3) no evidence for publication bias. In all, although the association between CTLA-4 polymorphisms and type 1 diabetes mellitus is weak, we suggest that it is real. Further studies are needed to clarify what variant of CTLA-4 (or some related gene) accounts for this association.
引用
收藏
页码：3919 / 3930
页数：12
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