Emerging strategies for the noninvasive diagnosis of nosocomial pneumonia

被引:14
|
作者
Liapikou, Adamantia [1 ]
Cilloniz, Catia [2 ]
Torres, Antoni [2 ]
机构
[1] Sotiria Chest Dis Hosp, Resp Dept 6, Mesog 152, Athens, Greece
[2] Univ Barcelona, CIBER Enfermedades Resp, IDIBAPS, Serv Pneumol,Inst Clin Torax,Hosp Clin, Barcelona, Spain
关键词
Nosocomial pneumonia; noninvasive; diagnosis; molecular; VOC; mass spectrometry; VENTILATOR-ASSOCIATED PNEUMONIA; SPECTRUM BETA-LACTAMASE; IONIZATION-MASS-SPECTROMETRY; BLOOD-STREAM INFECTIONS; GRAM-NEGATIVE BACILLI; INTENSIVE-CARE-UNIT; STAPHYLOCOCCUS-AUREUS; RAPID DIAGNOSIS; AUTOMATED MICROSCOPY; MOLECULAR DIAGNOSIS;
D O I
10.1080/14787210.2019.1635010
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Introduction: Hospital-acquired pneumonia is a common and therapeutically challenging diagnosis that can lead to severe sepsis, critical illness, and respiratory failure. In this review, we focus on efforts to enhance microbiological diagnosis of hospital-acquired pneumonia, including ventilator-associated pneumonia. Areas covered: A systematic literature review was conducted by searching Medline from inception to December 2018, including hand-searching of the reference lists for additional studies. The search strategy comprised the following common search terms: hospital pneumonia OR nosocomial pneumonia OR noninvasive OR molecular diagnostic tests (OR point-of-care systems OR VOC [i.e. volatile organic compounds]) OR rapid (or simple or quick test), including brand names for the most common commercial tests. Expert opinion: In recent years, the microbiological diagnosis of respiratory pathogens has improved significantly by the development and implementation of molecular diagnostic tests for pneumonia. Real-time polymerase chain reaction, hybridization, and mass spectrometry-based platforms dominate the scene, with microarray-based assays, multiplex polymerase chain reaction, and MALDI-TOF mass spectrometry capable of detecting the determinants of antimicrobial resistance (mainly beta-lactamase genes). Introducing these assays into routine clinical practice for rapid identification of the causative microbes and their resistance patterns could transform the care of pneumonia, improving antimicrobial selection, de-escalation, and stewardship.
引用
收藏
页码:523 / 533
页数:11
相关论文
共 50 条
  • [41] NOSOCOMIAL PNEUMONIA
    TOEWS, GB
    CLINICS IN CHEST MEDICINE, 1987, 8 (03) : 467 - 479
  • [42] Nosocomial pneumonia
    Waldemar G. Johanson
    Lisa L. Dever
    Intensive Care Medicine, 2003, 29 : 23 - 29
  • [43] Nosocomial pneumonia
    Johanson, WG
    Dever, LL
    INTENSIVE CARE MEDICINE, 2003, 29 (01) : 23 - 29
  • [44] Nosocomial pneumonia
    Lipchik, RJ
    Kuzo, RS
    RADIOLOGIC CLINICS OF NORTH AMERICA, 1996, 34 (01) : 47 - &
  • [45] NOSOCOMIAL PNEUMONIA
    HESSEN, MT
    KAYE, D
    CRITICAL CARE CLINICS, 1988, 4 (02) : 245 - 257
  • [46] Nosocomial pneumonia
    Mehta, RM
    Niederman, MS
    CURRENT OPINION IN INFECTIOUS DISEASES, 2002, 15 (04) : 387 - 394
  • [47] Nosocomial pneumonia
    Jebrak, G
    Mangiapan, G
    PRESSE MEDICALE, 1996, 25 (20): : 944 - 950
  • [48] Nosocomial pneumonia
    Diaz, Emili
    Martin-Loeches, Ignacio
    Valles, Jordi
    ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA, 2013, 31 (10): : 692 - 698
  • [49] NOSOCOMIAL PNEUMONIA
    HOYT, JW
    ANESTHESIOLOGY CLINICS OF NORTH AMERICA, 1989, 7 (04): : 869 - 881
  • [50] NOSOCOMIAL PNEUMONIA
    ORTQVIST, A
    NILSSON, A
    SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, 1992, 24 (04) : 555 - 555