Synthesis of (E)-3-(Isobenzofuran-3(1H)-ylidene)-indolin-2-ones by the Palladium-Catalyzed Intramolecular C-H Functionalization Process

被引：52

作者：

Peng, Peng ^{[1
]}

Tang, Bo-Xiao ^{[1
]}

Pi, Shao-Feng ^{[1
]}

Liang, Yun ^{[1
]}

Li, Jin -Heng ^{[1
,2
]}

机构：

[1] Hunan Normal Univ, Key Lab Chem Biol & Tradit Chinese Med Res, Minist Educ, Changsha 410081, Hunan, Peoples R China

[2] Hunan Univ, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 74卷 / 09期

基金：

中国国家自然科学基金;

关键词：

STEREOSELECTIVE-SYNTHESIS; 2-ALKYNYLARYL ISOCYANATES; CYCLIZATION REACTION; SELECTIVE OXIDATION; ORGANIC-CHEMICALS; DIRECT ARYLATION; 3-ALKYLIDENEOXINDOLES; ALKYNES; SUBSTITUENT; ELIMINATION;

D O I：

10.1021/jo900437p

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel and selective protocol has been developed for the synthesis of (E)-3-(isobenzofuran-3(1H)-ylidene)indolin-2-ones by Pd-catalyzed oxidative intramolecular C-H functionalization reactions of various 3-(2-(hydroxymethyl)aryl)-N-methyl-N-arylpropiolamides in moderate yields. Mechanisms involving a C-H activation process were proposed for this transformation on the basis of the observed values of kinetic isotope effects.

引用

页码：3569 / 3572

页数：4

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