Mild to Moderate Alzheimer Dementia with Insufficient Neuropathological Changes

被引：90

作者：

Serrano-Pozo, Alberto ^{[1
,2
,10
]}

Qian, Jing ^{[3
]}

Monsell, Sarah E. ^{[4
,5
]}

Blacker, Deborah ^{[1
,6
,7
]}

Gomez-Isla, Teresa ^{[1
,2
]}

Betensky, Rebecca A. ^{[1
,7
]}

Growdon, John H. ^{[1
,2
]}

Johnson, Keith A. ^{[1
,2
]}

Frosch, Matthew P. ^{[1
,8
]}

Sperling, Reisa A. ^{[1
,9
]}

Hyman, Bradley T. ^{[1
,2
]}

机构：

[1] Massachusetts Alzheimer Dis Res Ctr, Charlestown, MA 02129 USA

[2] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA

[3] Univ Massachusetts, Div Biostat & Epidemiol, Amherst, MA 01003 USA

[4] Univ Washington, Natl Alzheimers Coordinating Ctr, Seattle, WA 98195 USA

[5] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA

[6] Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA

[7] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA

[8] Massachusetts Gen Hosp, CS Kubik Lab Neuropathol, Boston, MA 02114 USA

[9] Brigham & Womens Hosp, Dept Neurol, Boston, MA 02115 USA

[10] Univ Iowa Hosp & Clin, Dept Neurol, Iowa City, IA 52242 USA

来源：

ANNALS OF NEUROLOGY | 2014年 / 75卷 / 04期

关键词：

NATIONAL INSTITUTE; DISEASE; PET; AUTOPSY;

D O I：

10.1002/ana.24125

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Recently, approximate to 16% of participants in an anti-A passive immunotherapy trial for mild-to-moderate Alzheimer disease (AD) had a negative baseline amyloid positron emission tomography (PET) scan. Whether they have AD or are AD clinical phenocopies remains unknown. We examined the 2005-2013 National Alzheimer's Coordinating Center autopsy database and found that approximate to 14% of autopsied subjects clinically diagnosed with mild-to-moderate probable AD have no or sparse neuritic plaques, which would expectedly yield a negative amyloid PET scan. More than half of these A-negative subjects have low neurofibrillary tangle Braak stages. These findings support the implementation of a positive amyloid biomarker as an inclusion criterion in future anti-A drug trials. Ann Neurol 2014;75:597-601

引用

页码：597 / 601

页数：5

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