Effects of the NMDA antagonist MK-801 on radial maze performance in histidine-deficient rats

被引：14
|
作者：
Nishiga, M [1 ]
Sugimoto, Y [1 ]
Taga, C [1 ]
Fujii, Y [1 ]
Kamei, C [1 ]
机构：
[1] Okayama Univ, Fac Pharmaceut Sci, Dept Pharmacol, Okayama 7008530, Japan
来源：
LIFE SCIENCES | 2002年 / 70卷 / 18期
关键词：
histamine; histidine; MK-801; glycine; radial maze; learning and memory;
D O I：
10.1016/S0024-3205(02)01504-7
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We examined the effects of a histidine-deficient diet on brain histamine contents as well as on learning and memory using the eight-ann radial maze in rats. A significant decrease in histamine content in the hippocampus was observed after long-term feeding of rats with a histidine-deficient diet. At the same time, significant enhancement of the acquisition process in radial maze performance was also observed. Pyrilamine did not show a significant effect on radial maze performance in histidine-deficient rats. On the other hand, pyrilamine caused a significant spatial memory deficit in control rats. Scopolamine was effective in inhibiting spatial memory in both histidine-deficient and control rats. MK-801 caused spatial memory deficits more potently in histidine-deficient rats than in controls. Brain glycine contents showed a significant increase in the hippocampus in histidine-deficient rats. These results indicated that the spatial memory deficits induced by MK-801 in histidine-deficient rats are closely related to increased glycine levels and activation of NMDA receptors. (C) 2002 Elsevier Science Inc. All rights reserved.
引用
收藏
页码：2199 / 2208
页数：10
相关论文
共 50 条
  • [1] Effects of NMDA antagonist MK-801 on radial maze performance in Zucker rats
    Nishiga, M
    Fujii, Y
    Sugimoto, Y
    Konishi, M
    Kamei, C
    BRAIN RESEARCH, 2002, 950 (1-2) : 127 - 129
  • [2] EFFECTS OF THE NMDA ANTAGONISTS CPP AND MK-801 ON RADIAL ARM MAZE PERFORMANCE IN RATS
    WARD, L
    MASON, SE
    ABRAHAM, WC
    PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1990, 35 (04) : 785 - 790
  • [3] Modeling the effects of the NMDA receptor antagonist MK-801 on timing in rats
    McAuley, J. Devin
    Miller, Jonathan P.
    Pang, Kevin C. H.
    BEHAVIORAL NEUROSCIENCE, 2006, 120 (05) : 1163 - 1168
  • [4] Effects of the NMDA antagonist MK-801 on the behavioural manifestations of antidepressants in rats
    Pruus, K.
    Allikmets, L.
    EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2009, 19 : S146 - S146
  • [5] EFFECTS OF MK-801, A NONCOMPETITIVE NMDA ANTAGONIST, ON LINGUOPHARYNGEAL EVENTS IN RATS
    MARCO, LA
    JOSHI, RS
    CHRONISTER, RB
    PSYCHOPHARMACOLOGY, 1991, 103 (04) : 462 - 466
  • [6] PHARMACOLOGY AND NEUROPROTECTIVE EFFECTS OF THE NMDA ANTAGONIST MK-801
    IVERSEN, LL
    WOODRUFF, GN
    KEMP, JA
    FOSTER, A
    GILL, R
    WONG, E
    PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1987, 28 (01) : 127 - 127
  • [7] Effects of the NMDA receptor antagonist MK-801 on short-interval timing in rats
    Miller, JP
    McAuley, JD
    Pang, KCH
    BEHAVIORAL NEUROSCIENCE, 2006, 120 (01) : 162 - 172
  • [8] The NMDA antagonist MK-801 affects nonspatial learning in preweanling rats
    Highfield, DA
    Nixon, K
    Amsel, A
    BEHAVIORAL NEUROSCIENCE, 1996, 110 (02) : 300 - 304
  • [9] CONTRASTING EFFECTS OF THE COMPETITIVE NMDA ANTAGONIST CPP AND THE NONCOMPETITIVE NMDA ANTAGONIST MK-801 ON PERFORMANCE OF AN OPERANT DELAYED MATCHING TO POSITION TASK IN RATS
    COLE, BJ
    KLEWER, M
    JONES, GH
    STEPHENS, DN
    PSYCHOPHARMACOLOGY, 1993, 111 (04) : 465 - 471
  • [10] ANXIOLYTIC-LIKE EFFECTS OF THE NONCOMPETITIVE NMDA ANTAGONIST MK-801
    XIE, ZC
    COMMISSARIS, RL
    PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1992, 43 (02) : 471 - 477
12345