Effects of NMDA antagonist MK-801 on radial maze performance in Zucker rats

被引：3
|
作者：
Nishiga, M [1 ]
Fujii, Y [1 ]
Sugimoto, Y [1 ]
Konishi, M [1 ]
Kamei, C [1 ]
机构：
[1] Okayama Univ, Fac Pharmaceut Sci, Dept Pharmacol, Okayama 7008530, Japan
来源：
BRAIN RESEARCH | 2002年 / 950卷 / 1-2期
关键词：
Zucker obese rat; pyrilamine; MK-801; radial maze; learning and memory;
D O I：
10.1016/S0006-8993(02)03012-3
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We examined the participation of the NMDA receptor in the histaminergic system using radial maze performance in Zucker rats. Although pyrilamine caused a significant effect on spatial memory deficit in lean rats, no significant spatial memory deficit was observed in obese rats. On the other hand, MK-801 caused significant spatial memory deficits in obese rats in comparison with lean rats. These results indicate that the histaminergic neuron is not closely related with the radial maze performance in obese rats. In addition, the potent effect of MK-801 observed in obese rats compared with lean rats may be responsible for the activation of NMDA receptors in obese rats. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：127 / 129
页数：3
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