Analysis of a single nucleotide polymorphism in codon 388 of the FGFR4 gene in malignant gliomas

被引：17
|
作者：
Mawrin, Christian
Kirches, Elmar
Diete, Sabine
Wiedemann, Falk R.
Schneider, Thomas
Firsching, Raimund
Kropf, Siegfried
Bogerts, Bernhard
Vorwerk, Christian K.
Kruger, Sabine
Dietzmann, Knut
机构：
[1] Otto Von Guericke Univ, Dept Neuropathol, Inst Neuropathol, D-39120 Magdeburg, Germany
[2] Otto Von Guericke Univ, Dept Neurol, D-39120 Magdeburg, Germany
[3] Otto Von Guericke Univ, Dept Neurosurg, D-39120 Magdeburg, Germany
[4] Otto Von Guericke Univ, Dept Biometr, D-39120 Magdeburg, Germany
[5] Otto Von Guericke Univ, Dept Psychiat, D-39120 Magdeburg, Germany
[6] Otto Von Guericke Univ, Dept Ophthalmol, D-39120 Magdeburg, Germany
[7] Otto Von Guericke Univ, Dept Pathol, D-39120 Magdeburg, Germany
来源：
CANCER LETTERS | 2006年 / 239卷 / 02期
关键词：
glioblastoma multiforme; FGFR4; survival;
D O I：
10.1016/j.canlet.2005.08.013
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The FGFR4 codon 388 polymorphism (Arg(388), Arg/Gly(388) or Gly(388)) was determined in glioblastoma multiforme (GBM), anaplastic astrocytomas (AA), diffuse astrocytomas (DA), and control muscles. Arg(388) was rare in AA, GBM, muscles, and was absent in DA. The Arg/Gly(388) and the Gly(388) frequency was equal among GBM and controls. FGFR4 expression was not related to codon 388 in GBM, and no survival differences between Arg/Gly(388) and Gly(388) tumors were found. U87 cells (Arg/Gly(388)) did not show higher invasion than U138 cells (Gly(388)). This suggests that the FGFR4 codon 388 status does not play a major role in malignant gliomas. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：239 / 245
页数：7
相关论文
共 50 条
  • [41] FGFR4 Gly388Arg polymorphism contributes to prostate cancer development and progression: A meta-analysis of 2618 cases and 2305 controls
    Bin Xu
    Na Tong
    Shu Q Chen
    Li X Hua
    Zeng J Wang
    Zheng D Zhang
    Ming Chen
    BMC Cancer, 11
  • [42] Joint association of polymorphism of the FGFR4 gene and mutation TP53 gene with bladder cancer prognosis
    Yang, Y. C.
    Lu, M. L.
    Rao, J. Y.
    Wallerand, H.
    Cai, L.
    Cao, W.
    Pantuck, A.
    Dalbagni, G.
    Reuter, V.
    Figlin, R. A.
    Belldegrun, A.
    Cordon-Cardo, C.
    Zhang, Z. F.
    BRITISH JOURNAL OF CANCER, 2006, 95 (11) : 1455 - 1458
  • [43] THE IMPACT OF FGFR4 ARG388 ON NEUROBLASTOMA INCIDENCE, OUTCOME, AND RESPONSE TO TREATMENT
    Whittle, Sarah
    Du, Melissa
    Woodfield, Sarah
    Zhang, Linna
    Okcu, Fatih
    Lupo, Philip
    Michael, Scheurer
    Peter, Zage
    PEDIATRIC BLOOD & CANCER, 2015, 62 : 100 - 100
  • [44] Joint association of polymorphism of the FGFR4 gene and mutation TP53 gene with bladder cancer prognosis
    Y C Yang
    M L Lu
    J Y Rao
    H Wallerand
    L Cai
    W Cao
    A Pantuck
    G Dalbagni
    V Reuter
    R A Figlin
    A Belldegrun
    C Cordon-Cardo
    Z F Zhang
    British Journal of Cancer, 2006, 95 : 1455 - 1458
  • [45] Single nucleotide polymorphism in fibroblast growth factor receptor 4 at codon 388 is associated with prognosis in high-grade soft tissue sarcoma
    Morimoto, Y
    Ozaki, T
    Ouchida, M
    Umehara, N
    Ohata, N
    Yoshida, A
    Shimizu, K
    Inoue, H
    CANCER, 2003, 98 (10) : 2245 - 2250
  • [46] Association between FGFR4 gene polymorphism and high-risk HPV infection cervical cancer
    Ya-Ping Li
    Lin Zhang
    Yu-Liang Zou
    Yan Yu
    Asian Pacific Journal of Tropical Medicine, 2017, (07) : 742 - 746
  • [47] Fibroblast Growth Factor Receptor 4 (FGFR4) in Cushing Disease Outcome: Influence of Expression and of the G388R Functional Polymorphism.
    Brito, L. P.
    Lerario, A. M.
    Bronstein, M. D.
    Mendonca, B. B.
    Fragoso, M. C. B. V.
    ENDOCRINE REVIEWS, 2010, 31 (03)
  • [48] Age related changes in human prostate are associated with the FGFR4 Arg388 allele
    Azzouzi, AR
    Turpin, E
    Crinquette, A
    Plassa, F
    Valeri, A
    Cormier, L
    Cancel-Tassin, G
    Fournier, G
    Mangin, P
    De Thé, H
    Cussenot, O
    JOURNAL OF UROLOGY, 2004, 171 (04): : 348 - 349
  • [49] Association between FGFR4 gene polymorphism and high-risk HPV infection cervical cancer
    Li, Ya-Ping
    Zhang, Lin
    Zou, Yu-Liang
    Yu, Yan
    ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE, 2017, 10 (07) : 742 - 746
  • [50] Involvement of the FGFr4 Arg388 allele in head and neck squamous cell carcinoma
    Streit, S
    Bange, J
    Fichtner, A
    Ihrler, S
    Issing, W
    Ullrich, A
    INTERNATIONAL JOURNAL OF CANCER, 2004, 111 (02) : 213 - 217
12345