Hashimoto's Encephalopathy Presenting with Smoldering Limbic Encephalitis

被引：5
|
作者：
Nagano, Masahiro [1 ]
Kobayashi, Katsuya [1 ]
Yamada-Otani, Mayumi [1 ]
Kuzuya, Akira [1 ]
Matsumoto, Riki [1 ]
Oita, Jiro [2 ]
Yoneda, Makoto [3 ]
Ikeda, Akio [4 ]
Takahashi, Ryosuke [1 ]
机构：
[1] Kyoto Univ, Grad Sch Med, Dept Neurol, Kyoto, Japan
[2] Shimizu Hosp, Dept Neurol, Shizuoka, Japan
[3] Fukui Prefectural Univ, Fac Nursing & Social Welf Sci, Eiheiji, Fukui, Japan
[4] Kyoto Univ, Grad Sch Med, Dept Epilepsy Movement Disorders & Physiol, Kyoto, Japan
来源：
INTERNAL MEDICINE | 2019年 / 58卷 / 08期
关键词：
Hashimoto's encephalopathy; FDG-PET; video EEG; autoimmune limbic encephalitis; anti-NAE antibody; STEROID-RESPONSIVE ENCEPHALOPATHY; FDG-PET; ANTIBODIES; FREQUENT;
D O I：
10.2169/internalmedicine.1289-18
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Hashimoto's encephalopathy (HE) is a steroid-responsive autoimmune encephalopathy associated with Hashimoto thyroiditis. We herein report a case of HE manifesting "smoldering" limbic encephalitis with persisting symptoms and abnormalities on examinations. Although our patient experienced partial clinical remission after treatment, hippocampal hypermetabolism on [F-18] fluorodeoxyglucose positron emission tomography (FDG-PET) and subclinical seizures on video electroencephalography persisted. Hypermetabolism on FDG-PET was improved by additional prednisolone therapy. Thus, as with other autoimmune limbic encephalitis cases, HE can take a course of "smoldering" encephalitis. FDG-PET and electroencephalogram findings can reflect the disease activity degree in such patients, although with certain neurophysiological and biochemical distinctions.
引用
收藏
页码：1167 / 1172
页数：6
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