Multiple facets of TPP1 in telomere maintenance

被引：17

作者：

Rajavel, Malligarjunan ^{[1
]}

Mullins, Michael R. ^{[1
]}

Taylor, Derek J. ^{[1
,2
]}

机构：

[1] Case Western Reserve Univ, Sch Med, Dept Pharmacol, Cleveland, OH 44106 USA

[2] Case Western Reserve Univ, Sch Med, Dept Biochem, Cleveland, OH 44106 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS | 2014年 / 1844卷 / 09期

基金：

美国国家卫生研究院;

关键词：

Telomere; TPP1; Shelterin; Telomerase; DNA damage; Chromosome stability; SINGLE-STRANDED-DNA; END-BINDING-PROTEIN; CELL-CYCLE PROGRESSION; HUMAN-CHROMOSOMES; HUMAN POT1; POT1-TPP1; PROTEINS; GENOMIC STABILITY; LENGTH REGULATION; IMMORTAL CELLS; HUMAN RAP1;

D O I：

10.1016/j.bbapap.2014.04.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Telomeres are nucleoprotein complexes that cap the ends of all linear chromosomes and function to prevent aberrant repair and end-to-end chromosome fusions. In somatic cells, telomere shortening is a natural part of the aging process as it occurs with each round of cell division. In germ and stem cells, however, the enzyme telomerase synthesizes telomere DNA to counter-balance telomere shortening and help maintain cellular proliferation. Of the primary telomere end-binding proteins, TPP1 has recently emerged as a primary contributor in protecting telomere DNA and in recruiting telomerase to the telomere ends. In this review, we summarize the current knowledge regarding the role of TPP1 in telomere maintenance. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：1550 / 1559

页数：10

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