Anti-inflammatory Ursane- and Oleanane-Type Triterpenoids from Vitex negundo var. cannabifolia

被引：50
|
作者：
Li, Man-Man [1 ,2 ]
Su, Xiao-Qin [1 ,2 ]
Sun, Jing [1 ,2 ]
Gu, Yu-Fan [1 ,2 ]
Huang, Zheng [1 ,2 ]
Zeng, Ke-Wu [3 ]
Zhang, Qian [1 ]
Zhao, Yun-Fang [1 ]
Ferreira, Daneel [4 ,5 ]
Zjawiony, Jordan K. [4 ,5 ]
Li, Jun [1 ]
Tu, Peng-Fei [1 ]
机构：
[1] Beijing Univ Chinese Med, Modern Res Ctr Tradit Chinese Med, Beijing 100029, Peoples R China
[2] Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 100102, Peoples R China
[3] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Hlth Sci Ctr, Beijing 100191, Peoples R China
[4] Univ Mississippi, Sch Pharm, Dept Biomol Sci, Div Pharmacognosy, University, MS 38677 USA
[5] Univ Mississippi, Sch Pharm, Pharmaceut Sci Res Inst, University, MS 38677 USA
来源：
JOURNAL OF NATURAL PRODUCTS | 2014年 / 77卷 / 10期
关键词：
PRUNELLA-VULGARIS; CONSTITUENTS; LIGNAN; PLANTS;
D O I：
10.1021/np500509q
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Six new polyoxygenated triterpenoids, cannabifolins A-F (1-6), and eight known triterpenoids, 7-14, were isolated from the leaves of Vitex negundo var. cannabifolia. The absolute configuration of cannabifolin A (1) was determined by single-crystal X-ray crystallographic analysis. Compounds 1 and 2 represent a class of rare natural pentacyclic triterpenoids bearing cis-fused C/D rings and are the first examples of 12,19-epoxy ursane- and oleanane-type triterpenoids. Compounds 3, 7, 8, and 14 exhibited inhibition of nitric oxide production in lipopolysaccharide-induced RAW 264.7 macrophages with IC50 values in the range 24.9-40.5 mu M.
引用
收藏
页码：2248 / 2254
页数：7
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