Furofuran lignan glucosides from the leaves of Vitex negundo var. cannabifolia

被引：8

作者：

Li, Yue-Ting ^{[1
,2
]}

Li, Man-Man ^{[1
,2
]}

Sun, Jing ^{[1
,2
]}

Zhu, Zhi-Xiang ^{[1
]}

Song, Yue-Lin ^{[1
]}

Pang, Dao-Ran ^{[1
,2
]}

Zheng, Jiao ^{[1
]}

Zhao, Yun-Fang ^{[1
]}

Tu, Peng-Fei ^{[1
]}

Li, Jun ^{[1
]}

机构：

[1] Beijing Univ Chinese Med, Modern Res Ctr Tradit Chinese Med, Beijing, Peoples R China

[2] Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2017年 / 31卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Verbenaceae; Vitex negundo var; cannabifolia; lignan glucoside; CONSTITUENTS;

D O I：

10.1080/14786419.2016.1255887

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Two new furofuran lignan glucosides, cannabilignin (1) and isocannabilignin (2), together with four known compounds (3-6), were isolated from the leaves of Vitex negundo var. cannabifolia. The structures of the isolates were elucidated by analysis of spectroscopic data. Compound 3 exhibited weak inhibition of nitric oxide production in lipopolysaccharide-stimulated BV-2 microglial cells with IC50 value of 69.1 +/- 5.8M.

引用

页码：918 / 924

页数：7

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