The role of the transcription factor Ets1 in carcinoma

被引：154

作者：

Dittmer, Juergen ^{[1
]}

机构：

[1] Univ Halle Wittenberg, Klin Gynakol, D-06120 Halle, Germany

来源：

SEMINARS IN CANCER BIOLOGY | 2015年 / 35卷

关键词：

Ets1; Drug resistance; EMT; Triple-negative breast cancer; HEPATOCYTE GROWTH-FACTOR; EPITHELIAL-MESENCHYMAL TRANSITION; ALPHA-B-CRYSTALLIN; MESSENGER-RNA EXPRESSION; CHEMOKINE RECEPTOR CXCR4; BREAST-CANCER CELLS; PML NUCLEAR-BODIES; DNA-BINDING; GENE-EXPRESSION; UP-REGULATION;

D O I：

10.1016/j.semcancer.2015.09.010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Ets1 belongs to the large family of the ETS domain family of transcription factors and is involved in cancer progression. In most carcinomas, Ets1 expression is linked to poor survival. In breast cancer, Ets1 is primarily expressed in the triple-negative subtype, which is associated with unfavorable prognosis. Ets1 contributes to the acquisition of cancer cell invasiveness, to EMT (epithelial-to-mesenchymal transition), to the development of drug resistance and neo-angiogenesis. The aim of this review is to summarize the current knowledge on the functions of Etsl in carcinoma progression and on the mechanisms that regulate Etsl activity in cancer. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：20 / 38

页数：19

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